ALK:PTN dimerization

Stable Identifier
R-HSA-201519
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of PTN is believed to induce ALK receptor dimerization, similar to other receptor tyrosine kinases (reviewed in Roskoski, 2013; Della Corte et al, 2018). Consistent with this, studies in rat with enforced dimerization of ALK lead to receptor activation, downstream signaling and neurite outgrowth in PC12 cells (Gouzi et al, 2005).

Literature References
PubMed ID Title Journal Year
16317043 Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells

Vigny, M, Brunet-de Carvalho, N, Moog-Lutz, C, Gouzi, JY

J Cell Sci 2005
29455642 Role and targeting of anaplastic lymphoma kinase in cancer

Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R

Mol. Cancer 2018
23201355 Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

Roskoski, R

Pharmacol. Res. 2013
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