Reactome | PARP1 [nucleoplasm]

PARP1 [nucleoplasm]

Stable Identifier

R-HSA-201568

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Poly (ADP-ribose) polymerase 1

Icon

Locations in the PathwayBrowser for interactor UniProt:P13010 XRCC5

Expand all

External Reference Information

External Reference

UniProt:P09874 PARP1

Gene Names

PARP1, ADPRT, PPOL

Chain

initiator methionine:, chain:2-1014, chain:2-214, chain:215-1014

Reference Genes

BioGPS Gene:142 PARP1

COSMIC (genes):PARP1 PARP1

CTD Gene:142 PARP1

dbSNP Gene:142 PARP1

ENSEMBL:ENSG00000143799 PARP1

ENSEMBL_homo_sapiens_GENE:ENSG00000143799.14 PARP1

HGNC:270 PARP1

KEGG Gene (Homo sapiens):142 PARP1

Monarch:142 PARP1

NCBI Gene:142 PARP1

OMIM:173870 PARP1

UCSC:P09874 PARP1

Reference Transcript

RefSeq:NM_001618.3 PARP1

Other Identifiers

11726247_s_at

11726248_x_at

11726249_a_at

11745950_a_at

1287_at

142

16699739

208644_PM_at

208644_at

2458786

2458787

2458788

2458789

2458790

2458791

2458792

2458796

2458797

2458801

2458803

2458805

2458806

2458808

2458810

2458813

2458816

2458817

2458818

2458819

2458820

2458821

2458823

2458825

2458827

2458828

2458829

2458832

2458838

2458839

2458840

3501577

3501611

3539486

3539490

3539492

3539496

41146_at

7924733

A_33_P3236921

A_33_P3290338

GE81045

GO:0000122

GO:0000228

GO:0000723

GO:0000781

GO:0000785

GO:0002376

GO:0003012

GO:0003677

GO:0003682

GO:0003684

GO:0003723

GO:0003824

GO:0003950

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006260

GO:0006281

GO:0006302

GO:0006310

GO:0006351

GO:0006355

GO:0006366

GO:0006915

GO:0006974

GO:0007005

GO:0007179

GO:0008152

GO:0008270

GO:0010332

GO:0010613

GO:0012501

GO:0016020

GO:0016051

GO:0016540

GO:0016604

GO:0016740

GO:0016757

GO:0016779

GO:0019899

GO:0019901

GO:0022414

GO:0023019

GO:0023052

GO:0030154

GO:0030225

GO:0030331

GO:0030592

GO:0031491

GO:0031625

GO:0032042

GO:0032200

GO:0032786

GO:0032869

GO:0032880

GO:0032991

GO:0032993

GO:0033148

GO:0034244

GO:0034599

GO:0034644

GO:0035861

GO:0036211

GO:0042802

GO:0042803

GO:0042826

GO:0043123

GO:0043226

GO:0043504

GO:0043596

GO:0044030

GO:0045087

GO:0045188

GO:0045824

GO:0045892

GO:0045944

GO:0046697

GO:0046872

GO:0048856

GO:0050790

GO:0051052

GO:0051287

GO:0051604

GO:0051901

GO:0055086

GO:0060391

GO:0060545

GO:0061629

GO:0070212

GO:0070213

GO:0070412

GO:0071168

GO:0071294

GO:0071560

GO:0071932

GO:0090734

GO:0098542

GO:0098772

GO:0140096

GO:0140294

GO:0140537

GO:0140805

GO:0140806

GO:0140807

GO:0140808

GO:0140815

GO:0140816

GO:0140817

GO:0140822

GO:0160049

GO:1900182

GO:1901135

GO:1903376

GO:1903518

GO:1904044

GO:1904178

GO:1904357

GO:1904646

GO:1904762

GO:1905051

GO:1905168

GO:1990090

GO:1990404

GO:1990966

GO:2001170

HMNXSV003052846

J03473_at

PH_hs_0010559

TC01003876.hg

g190266_3p_at

Participates

as an input of

as a component of

as a member of

PARP1,PARP2 [nucleoplasm] (Homo sapiens)

as an output of

PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)

Other forms of this molecule

polySUMO2,3-K203,K486-PARP1 [nucleoplasm]

monoSUMO1-K203,K486-PARP1 [nucleoplasm]

PAR-PARP1 [nucleoplasm]

Inferred To

adprt4 [nucleoplasm] (Dictyostelium discoideum)

Homologues of PARP1 [nucleoplasm] (Dictyostelium discoideum)

adprt2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of PARP1 [nucleoplasm] (Caenorhabditis elegans)

PARP1 [nucleoplasm] (Bos taurus)

PARP1 [nucleoplasm] (Canis familiaris)

PARP1 [nucleoplasm] (Danio rerio)

PARP1 [nucleoplasm] (Dictyostelium discoideum)

PARP1 [nucleoplasm] (Drosophila melanogaster)

PARP1 [nucleoplasm] (Gallus gallus)

PARP1 [nucleoplasm] (Mus musculus)

PARP1 [nucleoplasm] (Rattus norvegicus)

PARP1 [nucleoplasm] (Sus scrofa)

parp1 [nucleoplasm] (Xenopus tropicalis)

adprt1B [nucleoplasm] (Dictyostelium discoideum)

adprt1A [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001609.2

ZINC - World Drugs

PARP1_HUMAN

Guide to Pharmacology - Targets

2771

OpenTargets

ENSG00000143799

ZINC - FDA approved

PARP1_HUMAN

ZINC - Substances

PARP1_HUMAN

ZINC target

P09874

ZINC - Biogenic

PARP1_HUMAN

PRO

P09874

PDB

8FYY, 7SCZ, 2L31, 5XSR, 1WOK, 5WRY, 4OQA, 7KK5, 2N8A, 2L30, 5WS0, 6VKK, 5A00, 6NRJ, 4UND, 5DS3, 7S81, 2JVN, 2DMJ, 4GV7, 7AAC, 4ZZZ, 4HHZ, 1UK1, 7AAD, 4XHU, 3ODE, 7KK2, 7ONR, 6BHV, 8HE7, 7AAA, 3L3M, 5KPO, 7AAB, 4OPX, 4RV6, 5KPP, 3GJW, 7ONS, 3L3L, 7S6H, 7CMW, 6VKQ, 4R5W, 4PJT, 7S6M, 4OQB, 6NTU, 7KK6, 5KPN, 8FZ1, 5WTC, 2CS2, 1UK0, 6NRI, 7KK3, 4R6E, 3ODC, 2COK, 7KK4, 5WRQ, 4AV1, 3GN7, 6VKO, 3ODA, 7SCY, 4UXB, 8U4W, 5HA9, 7ONT, 6NRG, 4DQY, 6NRH, 6XVW, 5KPQ, 4HHY, 7S68, 2CR9, 4L6S, 5WRZ, 5XST, 8FYZ, 3OD8, 6GHK, 6NRF, 5WS1, 6M3I, 8G0H, 5XSU, 2RIQ, 2RD6, 2RCW

ZINC - Investigational

PARP1_HUMAN

ZINC - Metabolites

PARP1_HUMAN

IntEnz

2.4.2.30

GeneCards

P09874

HPA

ENSG00000143799-PARP1

Ensembl

ENSG00000143799, ENSP00000355759, ENST00000366794

Pharos - Targets

P09874

ZINC - Predictions - Purchasable

PARP1_HUMAN

HMDB Protein

HMDBP00913

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.878	10
UniProt:Q8IW19 APLF			0.875	9
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.853	9
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.845	12
UniProt:Q7Z2E3 APTX			0.771	10
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.75	5
UniProt:P46063 RECQ1			0.747	9
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.744	7
UniProt:Q14191 WRN	2	monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904) WRN [nucleoplasm] (R-HSA-67387)	0.739	8
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.725	5
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.662	5
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.643	6
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.623	3
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.623	2
UniProt:Q9BQ69 MACD1			0.623	3
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.609	3
UniProt:Q9Y530 OARD1			0.602	5
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.602	5
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.597	4
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.597	6
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.597	5
IntAct:EBI-22028558 HTR1A-PROMOTER			0.591	3
UniProt:BRCA2 ENSG00000139618			0.591	3
UniProt:Q86WJ1-1 CHD1L			0.591	3
UniProt:Q14684-1 RRP1B			0.584	4
UniProt:P08651 NFIC	1	NFIC [nucleoplasm] (R-HSA-60138)	0.564	2
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.564	2
UniProt:P11308 ERG			0.558	7
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.558	3
ChEBI:62878 XAV939			0.544	3
UniProt:Q02085 Snai1	1	Snai1 [nucleoplasm] (R-MMU-9756429)	0.544	3
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.537	6
UniProt:Q9P2D1 CHD7			0.527	3
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	3
UniProt:Q9UGN5 PARP2	2	PAR-PARP2 [nucleoplasm] (R-HSA-5651715) PARP2 [nucleoplasm] (R-HSA-174874)	0.527	2
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	5
UniProt:Q14684 RRP1B			0.527	2
UniProt:O75367 H2AY			0.527	3
UniProt:P49916 LIG3	1	LIG3 [nucleoplasm] (R-HSA-53789)	0.527	2
UniProt:P06746 POLB	2	PolyUb-POLB [nucleoplasm] (R-HSA-6783152) POLB [nucleoplasm] (R-HSA-53845)	0.527	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.527	3
IntAct:EBI-11426955 1082A			0.524	3
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.524	2
UniProt:P54577 YARS1	1	YARS [cytosol] (R-HSA-379560)	0.524	5
UniProt:Q13007 IL24	1	IL24 [extracellular region] (R-HSA-448438)	0.508	2
UniProt:O60741 HCN1	1	HCN1 [plasma membrane] (R-HSA-977503)	0.499	4
UniProt:P49715 CEBPA	1	CEBPA [nucleoplasm] (R-HSA-381289)	0.499	2
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [nucleoplasm] (R-HSA-266221) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.483	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.463	10
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.462	3
UniProt:Q5T7N2 LITD1			0.462	5

Cite Us!