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PRKN [cytosol]
Stable Identifier
R-HSA-201579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PARK2, Parkin, E3 ubiquitin-protein ligase parkin
Icon
Locations in the PathwayBrowser for interactor UniProt:O60260 PARK2
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Aggrephagy (Homo sapiens)
Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
PRKN binds p-S-Ub:MOM proteins (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
PARK2 binds SNCAIP (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
PARK2 autoubiquitinates (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60260 PARK2
Gene Names
PARK2, PRKN
Chain
chain:1-465
Reference Genes
BioGPS Gene:5071 PARK2
CTD Gene:5071 PARK2
dbSNP Gene:5071 PARK2
ENSEMBL:ENSG00000185345 PARK2
ENSEMBL_homo_sapiens_GENE:ENSG00000185345.25 PARK2
HGNC:8607 PARK2
KEGG Gene (Homo sapiens):5071 PARK2
Monarch:5071 PARK2
NCBI Gene:5071 PARK2
OMIM:602544 PARK2
UCSC:O60260 PARK2
Reference Transcript
RefSeq:NM_004562.2 PARK2
RefSeq:NM_013988.2 PARK2
RefSeq:NM_013987.2 PARK2
Other Identifiers
11740616_a_at
11740617_x_at
11741869_x_at
11741870_a_at
11750453_s_at
11758324_s_at
1555668_PM_a_at
1555668_a_at
17025440
207058_PM_s_at
207058_s_at
2983144
2983145
2983146
2983147
2983148
2983149
2983152
2983160
2983209
2983217
2983258
2983288
2983308
2983309
2983321
2983326
2983327
2983351
2983399
33019_at
5071
8130645
86935_r_at
A_23_P136077
A_23_P147465
GE53239
GO:0000122
GO:0000151
GO:0000209
GO:0000266
GO:0000422
GO:0000423
GO:0001664
GO:0001933
GO:0001963
GO:0001964
GO:0003714
GO:0003779
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005794
GO:0005829
GO:0005975
GO:0006351
GO:0006355
GO:0006511
GO:0006513
GO:0006807
GO:0006886
GO:0006914
GO:0006979
GO:0007005
GO:0007010
GO:0007417
GO:0007612
GO:0007626
GO:0008013
GO:0008092
GO:0008270
GO:0008344
GO:0009056
GO:0010498
GO:0010506
GO:0010628
GO:0010629
GO:0010636
GO:0010637
GO:0010821
GO:0010906
GO:0010994
GO:0012501
GO:0014059
GO:0014069
GO:0015631
GO:0016020
GO:0016192
GO:0016235
GO:0016236
GO:0016567
GO:0016607
GO:0016740
GO:0017124
GO:0019538
GO:0019899
GO:0019900
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030165
GO:0030544
GO:0031072
GO:0031396
GO:0031410
GO:0031624
GO:0031625
GO:0031647
GO:0031648
GO:0032092
GO:0032232
GO:0032368
GO:0032436
GO:0032991
GO:0033132
GO:0034599
GO:0034620
GO:0034976
GO:0035249
GO:0035519
GO:0036211
GO:0036503
GO:0042053
GO:0042415
GO:0042417
GO:0042802
GO:0042826
GO:0042981
GO:0042995
GO:0043005
GO:0043123
GO:0043130
GO:0043161
GO:0043226
GO:0043274
GO:0043388
GO:0043524
GO:0044238
GO:0044314
GO:0044828
GO:0044877
GO:0045202
GO:0045732
GO:0045944
GO:0046329
GO:0046676
GO:0046872
GO:0046928
GO:0048471
GO:0048856
GO:0050804
GO:0050821
GO:0050877
GO:0051087
GO:0051582
GO:0051583
GO:0051865
GO:0051881
GO:0060544
GO:0060828
GO:0061024
GO:0061630
GO:0061734
GO:0065003
GO:0070050
GO:0070534
GO:0070585
GO:0070842
GO:0070936
GO:0070979
GO:0071287
GO:0071704
GO:0085020
GO:0090090
GO:0090141
GO:0090201
GO:0097237
GO:0097413
GO:0097602
GO:0098691
GO:0098779
GO:0098793
GO:0099073
GO:0099074
GO:0140096
GO:0140110
GO:0140251
GO:1900242
GO:1900407
GO:1901526
GO:1901800
GO:1902236
GO:1902254
GO:1902283
GO:1902530
GO:1902803
GO:1903214
GO:1903265
GO:1903351
GO:1903377
GO:1903382
GO:1903542
GO:1903861
GO:1904049
GO:1905281
GO:1905366
GO:1905477
GO:1990000
GO:1990381
GO:1990444
GO:1990452
GO:2000377
GO:2000378
HMNXSV003033740
Hs2.132954.6.S1_3p_s_at
ILMN_1714511
ILMN_2395692
PH_hs_0007979
TC06002286.hg
g4758883_3p_a_at
Participates
as a component of
ATXN3:PARK2 [cytosol] (Homo sapiens)
PARK2:SNCAIP [cytosol] (Homo sapiens)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
as an input of
PARK2 autoubiquitinates (Homo sapiens)
PARK2 binds SNCAIP (Homo sapiens)
PRKN binds p-S-Ub:MOM proteins (Homo sapiens)
Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
polyUb-PARK2 [cytosol]
p-S9-PRKN [cytosol]
p-S65-PRKN [cytosol]
Inferred To
PRKN [cytosol]
(Bos taurus)
PRKN [cytosol]
(Canis familiaris)
PRKN [cytosol]
(Dictyostelium discoideum)
PRKN [cytosol]
(Drosophila melanogaster)
PRKN [cytosol]
(Gallus gallus)
PRKN [cytosol]
(Mus musculus)
PRKN [cytosol]
(Plasmodium falciparum)
PRKN [cytosol]
(Rattus norvegicus)
PRKN [cytosol]
(Saccharomyces cerevisiae)
PRKN [cytosol]
(Schizosaccharomyces pombe)
Homologues of PRKN [cytosol]
(Dictyostelium discoideum)
Ghost homologue of PRKN [cytosol]
(Caenorhabditis elegans)
Ghost homologue of PRKN [cytosol]
(Sus scrofa)
prkn [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_054642.2
,
NP_004553.2
,
NP_054643.2
GeneCards
O60260
HPA
ENSG00000185345-PRKN
Ensembl
ENST00000366897
,
ENST00000366896
,
ENST00000479615
,
ENST00000366898
,
ENSP00000434414
,
ENSP00000355865
,
ENSP00000355863
,
ENSG00000185345
,
ENSP00000355862
PRO
O60260
Pharos - Targets
O60260
Orphanet
16608
HMDB Protein
HMDBP07955
PDB
4I1F
,
2JMO
,
5C9V
,
5N38
,
1IYF
,
4I1H
,
4BM9
,
5TR5
,
6GLC
,
6N13
,
5C1Z
,
5C23
,
5N2W
,
6HUE
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BXM7 PINK1
5
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
0.748
7
UniProt:Q15645 PCH2
0.712
4
UniProt:P49792 RANBP2
6
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(R-HSA-4551720)
monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
(R-HSA-4551599)
RANBP2 [nuclear envelope]
(R-HSA-2993756)
RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9718443)
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702002)
RANBP2 [cytosol]
(R-HSA-157703)
0.639
11
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.623
10
IntAct:EBI-4399559 UBIQ
0.623
2
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.618
5
UniProt:P68510 Ywhah
1
14-3-3 eta [cytosol]
(R-MMU-1445091)
0.611
6
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.602
6
UniProt:Q6NUN9 ZNF746
1
ZNF746 [nucleoplasm]
(R-HSA-2586599)
0.591
6
UniProt:Q8IZ52-2 CHPF
0.581
5
UniProt:O95140 MFN2
5
MFN2 [mitochondrial outer membrane]
(R-HSA-992714)
Ub-MFN2 [mitochondrial outer membrane]
(R-HSA-9835010)
K48polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-5205668)
K63polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-9834043)
p-S65-Ub:MFN2 [mitochondrial outer membrane]
(R-HSA-9834980)
0.576
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P41220 RGS2
1
RGS2 [plasma membrane]
(R-HSA-939787)
0.553
2
UniProt:Q9BXM7-1 PINK1
0.544
2
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.527
2
UniProt:Q8IXI2 RHOT1
2
RHOT1 [mitochondrial outer membrane]
(R-HSA-3006728)
PolyUb-RHOT1 [mitochondrial outer membrane]
(R-HSA-6783139)
0.524
3
UniProt:O14818-1 PSMA7
0.524
5
UniProt:Q16342 PDCD2
0.508
5
UniProt:Q99IB8-PRO_0000045592
0.508
3
UniProt:Q9Z2Q6 SEPT5
0.508
2
UniProt:O35964
1
Sh3gl1 [cytosol]
(R-RNO-8867732)
0.462
2
UniProt:O35179 Sh3gl2
5
Sh3gl2 [Golgi membrane]
(R-RNO-351189)
Sh3gl2 [clathrin-coated endocytic vesicle membrane]
(R-RNO-2130629)
Endophilin [plasma membrane]
(R-RNO-182026)
Sh3gl2 [plasma membrane]
(R-RNO-177495)
Sh3gl2 [cytosol]
(R-RNO-182958)
0.462
2
UniProt:Q99963-3 SH3GL3
0.462
2
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