Reactome | PRKN [cytosol]

PRKN [cytosol]

Stable Identifier

R-HSA-201579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PARK2, Parkin, E3 ubiquitin-protein ligase parkin

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Locations in the PathwayBrowser for interactor UniProt:O95140 MFN2

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External Reference Information

External Reference

UniProt:O60260 PRKN

Gene Names

PRKN, PARK2

Chain

chain:1-465

Reference Genes

BioGPS Gene:5071 PRKN

COSMIC (genes):PRKN PRKN

CTD Gene:5071 PRKN

dbSNP Gene:5071 PRKN

ENSEMBL:ENSG00000185345 PRKN

HGNC:8607 PRKN

KEGG:hsa:5071 PRKN

Monarch:5071 PRKN

NCBI Gene:5071 PRKN

OMIM:602544 PRKN

UCSC:O60260 PRKN

Reference Transcript

Participates

as a component of

as an input of

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Other forms of this molecule

p-S65-PRKN [cytosol]

p-S9-PRKN [cytosol]

polyUb-PARK2 [cytosol]

Inferred To

PRKN [cytosol] (Bos taurus)

PRKN [cytosol] (Canis familiaris)

Prkn [cytosol] (Mus musculus)

Prkn [cytosol] (Rattus norvegicus)

HEL1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of PRKN [cytosol] (Dictyostelium discoideum)

Ghost homologue of PRKN [cytosol] (Plasmodium falciparum)

Ghost homologue of PRKN [cytosol] (Sus scrofa)

prkn [cytosol] (Danio rerio)

pdr-1 [cytosol] (Caenorhabditis elegans)

park [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_054642.2, NP_054643.2, NP_004553.2

ENSEMBL

ENST00000366897, ENST00000366896, ENSP00000355863, ENSP00000355862, ENSP00000355865, ENSG00000185345, ENSP00000434414, ENST00000479615, ENST00000366898

OpenTargets

ENSG00000185345

GeneCards

PRKN

HPA

ENSG00000185345-PRKN

PRO

O60260

Pharos - Targets

O60260

Orphanet

PRKN

GlyGen

O60260

HMDB Protein

HMDBP07955

PDB

6GLC, 2JMO, 6N13, 8IK6, 5C1Z, 5N38, 5N2W, 8WZN, 4I1F, 8JWV, 1IYF, 8WZO, 4BM9, 5C23, 5TR5, 6HUE, 8IKV, 4I1H, 5C9V

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXM7 PINK1	5	p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.748	7
UniProt:Q15645 PCH2			0.712	4
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.639	11
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.623	10
UniProt:O60260 PRKN	4	PRKN [cytosol] (R-HSA-201579) p-S65-PRKN [cytosol] (R-HSA-9834954) p-S9-PRKN [cytosol] (R-HSA-9793481) polyUb-PARK2 [cytosol] (R-HSA-5689094)	0.618	5
UniProt:P68510 Ywhah	1	14-3-3 eta [cytosol] (R-MMU-1445091)	0.611	6
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.602	6
UniProt:Q6NUN9 ZNF746	1	ZNF746 [nucleoplasm] (R-HSA-2586599)	0.591	6
UniProt:Q8IZ52-2 CHPF			0.581	5
UniProt:O95140 MFN2	5	p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-HSA-9834980) K63polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-9834043) K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) Ub-MFN2 [mitochondrial outer membrane] (R-HSA-9835010) MFN2 [mitochondrial outer membrane] (R-HSA-992714)	0.576	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:Q9BXM7-1 PINK1			0.544	2
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.527	2
UniProt:O14818-1 PSMA7			0.524	5
UniProt:Q8IXI2 RHOT1	2	PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139) RHOT1 [mitochondrial outer membrane] (R-HSA-3006728)	0.524	3
UniProt:Q9Z2Q6 SEPT5			0.508	2
UniProt:Q99IB8-PRO_0000045592			0.508	3
UniProt:Q16342 PDCD2			0.508	5
UniProt:Q99963-3 SH3GL3			0.462	2
UniProt:O35179 Sh3gl2	5	Sh3gl2 [Golgi membrane] (R-RNO-351189) Sh3gl2 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130629) Endophilin [plasma membrane] (R-RNO-182026) Sh3gl2 [plasma membrane] (R-RNO-177495) Sh3gl2 [cytosol] (R-RNO-182958)	0.462	2
UniProt:O35964	1	Sh3gl1 [cytosol] (R-RNO-8867732)	0.462	2

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