Reactome | PRKN [cytosol]

PRKN [cytosol]

Stable Identifier

R-HSA-201579

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PARK2, Parkin, E3 ubiquitin-protein ligase parkin

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Locations in the PathwayBrowser for interactor UniProt:P41220 RGS2

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External Reference Information

External Reference

UniProt:O60260 PARK2

Gene Names

PARK2, PRKN

Chain

chain:1-465

Reference Genes

BioGPS Gene:5071 PRKN

COSMIC (genes):PRKN PARK2

CTD Gene:5071 PRKN

dbSNP Gene:5071 PRKN

ENSEMBL:ENSG00000185345 PARK2

HGNC:8607 PRKN

KEGG:hsa:5071 PRKN

Monarch:5071 PRKN

NCBI Gene:5071 PRKN

OMIM:602544 PRKN

UCSC:O60260 PRKN

Reference Transcript

Participates

as a component of

as an input of

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Other forms of this molecule

p-S65-PRKN [cytosol]

p-S9-PRKN [cytosol]

polyUb-PARK2 [cytosol]

Inferred To

PRKN [cytosol] (Bos taurus)

PRKN [cytosol] (Canis familiaris)

PRKN [cytosol] (Dictyostelium discoideum)

PRKN [cytosol] (Drosophila melanogaster)

PRKN [cytosol] (Gallus gallus)

PRKN [cytosol] (Mus musculus)

PRKN [cytosol] (Plasmodium falciparum)

PRKN [cytosol] (Rattus norvegicus)

PRKN [cytosol] (Saccharomyces cerevisiae)

PRKN [cytosol] (Schizosaccharomyces pombe)

Homologues of PRKN [cytosol] (Dictyostelium discoideum)

Ghost homologue of PRKN [cytosol] (Caenorhabditis elegans)

Ghost homologue of PRKN [cytosol] (Sus scrofa)

prkn [cytosol] (Danio rerio)

Cross References

RefSeq

NP_004553.2, NP_054642.2, NP_054643.2

OpenTargets

ENSG00000185345

ENSEMBL

ENST00000479615, ENSP00000355862, ENSP00000355863, ENSP00000434414, ENST00000366896, ENST00000366897, ENSP00000355865, ENSG00000185345, ENST00000366898

GeneCards

PRKN

HPA

ENSG00000185345-PRKN

PRO

O60260

Pharos - Targets

O60260

GlyGen

O60260

Orphanet

PRKN

HMDB Protein

HMDBP07955

PDB

5N2W, 5N38, 2JMO, 4BM9, 5C1Z, 5C23, 8IK6, 4I1H, 5C9V, 8IKV, 4I1F, 8JWV, 6GLC, 8WZN, 6HUE, 1IYF, 5TR5, 6N13, 8WZO

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXM7 PINK1	5	p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.748	7
UniProt:Q15645 PCH2			0.712	4
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.639	11
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.623	10
UniProt:O60260 PARK2	4	PRKN [cytosol] (R-HSA-201579) p-S65-PRKN [cytosol] (R-HSA-9834954) p-S9-PRKN [cytosol] (R-HSA-9793481) polyUb-PARK2 [cytosol] (R-HSA-5689094)	0.618	5
UniProt:P68510 Ywhah	1	14-3-3 eta [cytosol] (R-MMU-1445091)	0.611	6
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.602	6
UniProt:Q6NUN9 ZNF746	1	ZNF746 [nucleoplasm] (R-HSA-2586599)	0.591	6
UniProt:Q8IZ52-2 CHPF			0.581	5
UniProt:O95140 MFN2	5	p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-HSA-9834980) K63polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-9834043) K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) Ub-MFN2 [mitochondrial outer membrane] (R-HSA-9835010) MFN2 [mitochondrial outer membrane] (R-HSA-992714)	0.576	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:Q9BXM7-1 PINK1			0.544	2
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.527	2
UniProt:O14818-1 PSMA7			0.524	5
UniProt:Q8IXI2 RHOT1	2	PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139) RHOT1 [mitochondrial outer membrane] (R-HSA-3006728)	0.524	3
UniProt:Q9Z2Q6 SEPT5			0.508	2
UniProt:Q99IB8-PRO_0000045592			0.508	3
UniProt:Q16342 PDCD2			0.508	5
UniProt:O35179 Sh3gl2	5	Sh3gl2 [Golgi membrane] (R-RNO-351189) Sh3gl2 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130629) Endophilin [plasma membrane] (R-RNO-182026) Sh3gl2 [plasma membrane] (R-RNO-177495) Sh3gl2 [cytosol] (R-RNO-182958)	0.462	2
UniProt:Q99963-3 SH3GL3			0.462	2
UniProt:O35964	1	Sh3gl1 [cytosol] (R-RNO-8867732)	0.462	2

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