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PKP1 [plasma membrane]
Stable Identifier
R-HSA-201597
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plakophilin 1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Apoptotic cleavage of cell adhesion proteins (Homo sapiens)
Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13835 PKP1
Gene Names
PKP1
Chain
chain:1-747
Reference Genes
BioGPS Gene:5317 PKP1
COSMIC (genes):PKP1 PKP1
CTD Gene:5317 PKP1
dbSNP Gene:5317 PKP1
ENSEMBL:ENSG00000081277 PKP1
ENSEMBL_homo_sapiens_GENE:ENSG00000081277.13 PKP1
HGNC:9023 PKP1
KEGG Gene (Homo sapiens):5317 PKP1
Monarch:5317 PKP1
NCBI Gene:5317 PKP1
OMIM:601975 PKP1
UCSC:Q13835 PKP1
Reference Transcript
RefSeq:NM_000299.3 PKP1
RefSeq:NM_001005337.2 PKP1
Other Identifiers
11719135_a_at
11739945_a_at
11739946_a_at
16675763
205724_PM_at
205724_at
221854_PM_at
221854_at
2374605
2374606
2374607
2374613
2374621
2374622
2374624
2374625
2374626
2374628
2374629
2374630
2374631
2374632
2374633
2374634
2374635
2374642
2374643
2374644
2374645
32380_at
51214_at
5317
7908672
A_23_P23296
A_33_P3393971
GE61463
GO:0001533
GO:0005198
GO:0005515
GO:0005521
GO:0005634
GO:0005654
GO:0005737
GO:0005856
GO:0005882
GO:0005886
GO:0005912
GO:0007010
GO:0007043
GO:0007155
GO:0007165
GO:0010628
GO:0016071
GO:0019215
GO:0023052
GO:0030057
GO:0030280
GO:0031410
GO:0034330
GO:0043226
GO:0045110
GO:0045296
GO:0070161
GO:0098609
GO:0101003
GO:1902373
GO:1990124
HMNXSV003054966
Hs.292911.0.S1_3p_at
Hs.292911.0.S1_3p_x_at
ILMN_1663454
ILMN_1716424
ILMN_1721284
PH_hs_0023741
TC01001658.hg
Z34974_s_at
Z73677_at
g4505840_3p_at
Participates
as a member of
Plakophilins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
as an input of
Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)
Other forms of this molecule
PKP1 [cornified envelope]
PKP1 [ficolin-1-rich granule membrane]
PKP1(?-?) [plasma membrane]
Inferred To
Pkp1 [plasma membrane]
(Mus musculus)
Pkp1 [plasma membrane]
(Rattus norvegicus)
p120ctn [plasma membrane]
(Drosophila melanogaster)
PKP1 [plasma membrane]
(Bos taurus)
PKP1 [plasma membrane]
(Canis familiaris)
PKP1 [plasma membrane]
(Gallus gallus)
PKP1 [plasma membrane]
(Sus scrofa)
jac-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001005337.1
,
NP_000290.2
OpenTargets
ENSG00000081277
GeneCards
Q13835
HPA
ENSG00000081277-PKP1
Ensembl
ENSP00000356293
,
ENST00000367324
,
ENSG00000081277
,
ENSP00000263946
,
ENST00000352845
,
ENST00000263946
,
ENSP00000295597
PRO
Q13835
Pharos - Targets
Q13835
Orphanet
15103
PDB
1XM9
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63HR2 TENS2
0.556
3
UniProt:Q9UHL9 GT2D1
0.508
2
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