Reactome | Caspase-mediated cleavage of alpha adducin

Caspase-mediated cleavage of alpha adducin

Stable Identifier

R-HSA-201608

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Caspase-mediated cleavage of alpha adducin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The cortical actin cytoskeletal network is lost during apoptosis. During apoptosis, increased phosphorylation of the actin capping protein alpha-adducin leads to its dissociation from the cytoskeleton. The caspase-3-mediated cleavage cleavage of alpha adducin at Asp-Asp-Ser-Asp(633)-Ala prevents its reassociation (van de Water et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10823823	Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells Verbrugge, A, Jaken, S, Tijdens, IB, Dihal, AA, Huigsloot, M, Stevens, JL, Mulder, GJ, van de Water, B	J Biol Chem	2000