Caspase-mediated cleavage of alpha adducin

Stable Identifier
R-HSA-201608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The cortical actin cytoskeletal network is lost during apoptosis. During apoptosis, increased phosphorylation of the actin capping protein alpha-adducin leads to its dissociation from the cytoskeleton. The caspase-3-mediated cleavage cleavage of alpha adducin at Asp-Asp-Ser-Asp(633)-Ala prevents its reassociation (van de Water et al, 2000).
Literature References
PubMed ID Title Journal Year
10823823 Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells

Verbrugge, A, Jaken, S, Tijdens, IB, Dihal, AA, Huigsloot, M, Stevens, JL, Mulder, GJ, van de Water, B

J Biol Chem 2000
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Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

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