Caspase-mediated cleavage of Rock-1

Stable Identifier
R-HSA-201611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing (Sebbagh et al., 2001). Cleavage and activation of ROCK-1 by caspase-3 plays has also been shown to play a crucial role in in cardiac myocyte apoptosis (Chang et al., 2006).
Literature References
PubMed ID Title Journal Year
16983089 Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

Wei, L, Shah, VR, Schwartz, RJ, Xie, M, Entman, ML, Schneider, MD, Chang, J

Proc Natl Acad Sci U S A 2006
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!