Reactome | Caspase-mediated cleavage of gelsolin

Caspase-mediated cleavage of gelsolin

Stable Identifier

R-HSA-201622

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Gelsolin is cleaved by caspase-3 generating a constitutively
active fragment that can depolymerize F-actin contributing to actin cytoskeletal collapse (Kothakota et al., 1997)

Literature References

PubMed ID	Title	Journal	Year
9930654	Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines Libby, P, Kwiatkowski, DJ, Wu, Q, Hartwig, JH, Muszynski, M, Geng, YJ, Tang, JX, Azuma, T	Eur J Cell Biol	1998
9323209	Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis Koths, K, McGarry, TJ, Kwiatkowski, DJ, Klippel, A, Tang, J, Kothakota, S, Kirschner, MW, Reinhard, C, Chu, K, Azuma, T, Williams, LT	Science	1997