Reactome | STK4(1-487) [cytosol]

STK4(1-487) [cytosol]

Stable Identifier

R-HSA-201627

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

STK4, Serine/threonine-protein kinase 4, MST1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13043 STK4

Gene Names

STK4, KRS2, MST1

Chain

chain:1-487, chain:1-326, chain:327-487

Reference Genes

BioGPS Gene:6789 STK4

COSMIC (genes):MST1 MST1

COSMIC (genes):STK4 STK4

CTD Gene:6789 STK4

dbSNP Gene:6789 STK4

ENSEMBL:ENSG00000101109 STK4

HGNC:11408 STK4

KEGG:hsa:6789 STK4

Monarch:6789 STK4

NCBI Gene:6789 STK4

OMIM:604965 STK4

UCSC:Q13043 STK4

Reference Transcript

Participates

as a component of

STK4 dimer [cytosol] (Homo sapiens)

Other forms of this molecule

p-T183-STK4(1-487) [cytosol]

STK4(327-487) [cytosol]

p-T183-STK4(1-326) [cytosol]

Inferred To

STK4 [cytosol] (Bos taurus)

STK4 [cytosol] (Canis familiaris)

STK4 [cytosol] (Gallus gallus)

STK4 [cytosol] (Sus scrofa)

cst-1 [cytosol] (Caenorhabditis elegans)

hpo [cytosol] (Drosophila melanogaster)

cst-2 [cytosol] (Caenorhabditis elegans)

Homologues of STK4(1-487) [cytosol] (Caenorhabditis elegans)

Stk4 [cytosol] (Mus musculus)

Stk4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006273.1, XP_005260590.1, NP_001339314.1

ZINC - World Drugs

STK4_HUMAN

Guide to Pharmacology - Targets

2225

OpenTargets

ENSG00000101109

ENSEMBL

ENSP00000361892, ENSP00000361887, ENST00000372806, ENSG00000101109, ENST00000372801

ZINC - FDA approved

STK4_HUMAN

ZINC - Substances

STK4_HUMAN

ZINC - Biogenic

STK4_HUMAN

ZINC target

Q13043

PRO

Q13043

PDB

2JO8, 4NR2, 3COM, 5TWH, 4OH8, 6YAT, 5TWG, 8PAW, 8A5J, 8PAV

ZINC - Investigational

STK4_HUMAN

IntEnz

2.7.11.1

GeneCards

STK4

HPA

ENSG00000101109-STK4

Pharos - Targets

Q13043

Orphanet

STK4

ZINC - Predictions - Purchasable

STK4_HUMAN

HMDB Protein

HMDBP01490

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4B6 SAV1	2	p-SAV1 [cytosol] (R-HSA-2028276) SAV1 [cytosol] (R-HSA-2028283)	0.942	23
UniProt:P50749 RASF2			0.926	19
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.914	20
UniProt:Q9NS23 RASF1			0.886	11
UniProt:Q8WWW0 RASF5			0.88	9
UniProt:Q9H2L5 RASF4			0.829	7
UniProt:Q86WH2 RASF3			0.823	7
UniProt:Q14BN4 SLMAP			0.787	8
UniProt:Q6ZTQ3 RASF6			0.779	6
UniProt:Q9H8S9 MOB1A	2	p-T12,T35-MOB1A [cytosol] (R-HSA-2028628) MOB1A [cytosol] (R-HSA-2028568)	0.747	9
UniProt:Q9NS23-2 RASSF1			0.729	4
UniProt:P46821 MAP1B	1	MAP1B(2-2206) [cytosol] (R-HSA-9836954)	0.725	4
UniProt:Q66K74 MAP1S			0.706	5
UniProt:Q9GZQ8 MAP1LC3B	4	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [extracellular exosome] (R-HSA-9959986)	0.688	8
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.678	4
UniProt:Q06830 PRDX1	4	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) PRDX1 [extracellular region] (R-HSA-8958052) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.66	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.65	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.643	5
UniProt:Q7L9L4 MOB1B	2	p-T12,T35-MOB1B [cytosol] (R-HSA-2028643) MOB1B [cytosol] (R-HSA-2028569)	0.629	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.619	13
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.615	4
UniProt:P35700 Prdx1	4	p-T90-Prdx1 [cytosol] (R-MMU-8868582) Prdx1 [extracellular region] (R-MMU-8958052) Prdx1 [cytosol] (R-MMU-5629198) Prdx1 [cytosol] (R-MMU-8868585)	0.611	3
UniProt:Q8WWW0-2 RASSF5			0.581	4
UniProt:Q99MK9 RASF1			0.564	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.544	2
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.544	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.544	2
UniProt:P11021 HSPA5	7	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [plasma membrane] (R-HSA-9922467) HSPA5 [extracellular region] (R-HSA-351322)	0.527	3
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(1-176) [Golgi membrane] (R-HSA-187679)	0.527	2
UniProt:P04083 ANXA1	2	ANXA1 [extracellular region] (R-HSA-444539) ANXA1 [cytosol] (R-HSA-5263630)	0.527	2
UniProt:P09466 PAEP			0.527	3
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.527	4
UniProt:Q9UKB1 FBXW11	2	FBXW11 [cytosol] (R-HSA-976035) FBXW11 [nucleoplasm] (R-HSA-9953055)	0.527	2
UniProt:Q91VJ4	1	Stk38 [cytosol] (R-MMU-9715143)	0.525	2
UniProt:Q8WWW0-3 RASSF5			0.508	2
UniProt:Q13033 STRN3			0.483	3
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.483	2

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