Reactome | Caspase-mediated cleavage of vimentin at DSVD (85)

Caspase-mediated cleavage of vimentin at DSVD (85)

Stable Identifier

R-HSA-201628

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Caspase-mediated cleavage of vimentin at DSVD (85)

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Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This cleavage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Caspase-6 recognizes and cleaves C terminal side of Asp-429. Vimentin is cleaved at Asp85 by caspases-3 and -7 (Byun et al., 2001). This clevage generates a pro-apoptotic amino-terminal cleavage product (amino acids 1-85) that amplifies the cell death signal (Byun et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11423904	Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis Byun, Y, Chen, F, Chang, R, Trivedi, M, Green, KJ, Cryns, VL	Cell Death Differ	2001