Caspase-mediated cleavage of GAS2

Stable Identifier
R-HSA-201639
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Caspase-mediated cleavage of GAS2
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Cleavage of Gas2 during apoptosis is associated with changes of the microfilament system but does not interfere with its ability to bind F-actin (Brancolini et al., 1995).
Literature References
PubMed ID Title Journal Year
7489707 Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

Schneider, C, Brancolini, C, Benedetti, M

EMBO J 1995
10564664 Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis

Marzinotto, S, Benetti, R, Schneider, C, Brancolini, C, Sgorbissa, A

J Cell Sci 1999
Participants
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3, Caspase-7 [cytosol]

Physical Entity
Caspase-3, Caspase-7 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of GAS2 (Bos taurus)
Caspase-mediated cleavage of GAS2 (Canis familiaris)
Caspase-mediated cleavage of GAS2 (Gallus gallus)
Caspase-mediated cleavage of GAS2 (Mus musculus)
Caspase-mediated cleavage of GAS2 (Rattus norvegicus)
Caspase-mediated cleavage of GAS2 (Sus scrofa)
Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2007-09-03)
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