An anchoring protein, Endofin, recruits R-Smad1/5/8

Stable Identifier
R-HSA-201648
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Endofin is a FYVE domain-containing protein that strongly resembles SARA, the Smad anchor for receptor activation that facilitates TGF-beta signalling. Endofin acts in a similar manner as SARA, it binds to BMP-specific R-Smads, it localizes in early endosomes and it facilitates their phosphorylation, thus promoting signal transduction by the BMP receptors. However, it should be noted that endofin has also been reported to bind to the Co-Smad, Smad4, and to the TGF-beta type receptor, thus enhancing TGF-beta signalling. Since Smad4 is a common Smad that operates in the BMP-specific pathways, the latter observation might imply that endofin could regulate both TGF-beta and BMP signalling, a hypothesis still open for investigation.
Literature References
PubMed ID Title Journal Year
17356069 Endofin acts as a Smad anchor for receptor activation in BMP signaling

Cao, X, Chang, C, Nie, S, Wan, M, Shi, W, Xie, S

J Cell Sci 2007
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!