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ACVR2A [plasma membrane]
Stable Identifier
R-HSA-201659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ACVR2, Activin receptor type II, AVR2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
NODAL:p-NODAL Receptor [plasma membrane] (Homo sapiens)
p-Nodal Receptor [plasma membrane] (Homo sapiens)
p-ACVR1B:ACVR2:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Regulation of signaling by NODAL (Homo sapiens)
LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)
LEFTY1,2:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
The NODAL Receptor binds NODAL ligands (Homo sapiens)
NODAL Ligand:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
NODAL:p-ACVR1B:ACVR2:EGF-CFC [plasma membrane] (Homo sapiens)
p-ACVR1B:ACVR2:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin AB,B:ACVR2A,B:ACVR1C [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
Activin:ACVR2A,B:p-ACVR1B,C [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:p-ACVR1B [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Activin AB,B:ACVR2A,B:p-ACVR1C [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Formation of a heteromeric BMP receptor complex (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
Type II receptor phosphorylates type I receptor (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27037 ACVR2A
Gene Names
ACVR2A, ACVR2
Chain
signal peptide:1-19, chain:20-513
Reference Genes
BioGPS Gene:92 ACVR2A
COSMIC (genes):ACVR2A ACVR2A
CTD Gene:92 ACVR2A
dbSNP Gene:92 ACVR2A
ENSEMBL:ENSG00000121989 ACVR2A
ENSEMBL_homo_sapiens_GENE:ENSG00000121989.15 ACVR2A
HGNC:173 ACVR2A
KEGG Gene (Homo sapiens):92 ACVR2A
Monarch:92 ACVR2A
NCBI Gene:92 ACVR2A
OMIM:102581 ACVR2A
UCSC:P27037 ACVR2A
Reference Transcript
RefSeq:NM_001278579.1 ACVR2A
RefSeq:NM_001278580.1 ACVR2A
RefSeq:NM_001616.4 ACVR2A
Other Identifiers
11727163_a_at
11727164_at
11752492_a_at
16886308
205327_PM_s_at
205327_s_at
228416_PM_at
228416_at
2509558
2509560
2509561
2509562
2509578
2509585
2509586
2509587
2509589
2509590
2509591
2509592
2509594
2509597
2509598
2509599
2509600
2509601
2509611
2509613
35162_s_at
53468_at
62358_at
8045587
92
A_14_P109940
A_14_P122941
A_23_P153930
GE486534
GE58150
GO:0000166
GO:0001702
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005515
GO:0005524
GO:0005737
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007178
GO:0007283
GO:0007368
GO:0007498
GO:0008584
GO:0009952
GO:0009966
GO:0009986
GO:0015026
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017002
GO:0019838
GO:0022414
GO:0023052
GO:0030154
GO:0030165
GO:0030501
GO:0030509
GO:0032924
GO:0032927
GO:0034673
GO:0034711
GO:0036211
GO:0042475
GO:0042713
GO:0043084
GO:0043235
GO:0043621
GO:0045428
GO:0045648
GO:0045669
GO:0045944
GO:0046872
GO:0048179
GO:0048185
GO:0048706
GO:0048856
GO:0051171
GO:0060011
GO:0060089
GO:0060255
GO:0060391
GO:0071363
GO:0071773
GO:0080090
GO:0098821
GO:0140096
HMNXSV003013244
HMNXSV003051576
Hs.33412.0.A1_3p_at
ILMN_1670912
ILMN_2152711
M93415_at
PH_hs_0018877
TC02000923.hg
g10862696_3p_a_at
Participates
as a member of
Type II receptor [plasma membrane] (Homo sapiens)
ACVR2A,B [plasma membrane] (Homo sapiens)
as a component of
INHIBIN-A:TGFBR3:ACVR2A [plasma membrane] (Homo sapiens)
Inferred To
put [plasma membrane]
(Drosophila melanogaster)
acvr2a [plasma membrane]
(Xenopus tropicalis)
Acvr2a [plasma membrane]
(Mus musculus)
ACVR2A [plasma membrane]
(Bos taurus)
ACVR2A [plasma membrane]
(Caenorhabditis elegans)
ACVR2A [plasma membrane]
(Canis familiaris)
ACVR2A [plasma membrane]
(Gallus gallus)
ACVR2A [plasma membrane]
(Rattus norvegicus)
ACVR2A [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001265509.1
,
NP_001265508.1
,
NP_001607.1
ZINC - World Drugs
AVR2A_HUMAN
Guide to Pharmacology - Targets
1791
OpenTargets
ENSG00000121989
ZINC - FDA approved
AVR2A_HUMAN
ZINC - Substances
AVR2A_HUMAN
ZINC - Biogenic
AVR2A_HUMAN
ZINC target
P27037
PRO
P27037
PDB
3Q4T
,
4ASX
,
3SOC
,
7U5P
,
5NH3
ZINC - Investigational
AVR2A_HUMAN
IntEnz
2.7.11.30
GeneCards
P27037
HPA
ENSG00000121989-ACVR2A
Ensembl
ENSP00000241416
,
ENSP00000439988
,
ENST00000535787
,
ENSG00000121989
,
ENST00000404590
,
ENST00000241416
,
ENSP00000384338
Pharos - Targets
P27037
ZINC - Predictions - Purchasable
AVR2A_HUMAN
HMDB Protein
HMDBP01519
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