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SMARCA4 [nucleoplasm]
Stable Identifier
R-HSA-201686
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
BRG1, BAF190A, SNF2B
Locations in the PathwayBrowser for interactor UniProt:Q92785 DPF2
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
BRWD1 binds SMARCA4 (Homo sapiens)
SMARCA4 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
EGR2 and SOX10-mediated initiation of Schwann cell myelination (Homo sapiens)
EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)
SMARCA4 [nucleoplasm] (Homo sapiens)
SOX10 dimer binds the POU3F1 promoter (Homo sapiens)
SMARCA4 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
BRWD1 binds SMARCA4 (Homo sapiens)
SMARCA4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin recruits SMARCA4 (Homo sapiens)
SMARCA4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51532 SMARCA4
Gene Names
SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4
Chain
chain:1-1647
Reference Genes
BioGPS Gene:6597 SMARCA4
COSMIC (genes):SMARCA4 SMARCA4
CTD Gene:6597 SMARCA4
dbSNP Gene:6597 SMARCA4
ENSEMBL:ENSG00000127616 SMARCA4
HGNC:11100 SMARCA4
KEGG:hsa:6597 SMARCA4
Monarch:6597 SMARCA4
NCBI Gene:6597 SMARCA4
OMIM:603254 SMARCA4
UCSC:P51532 SMARCA4
Reference Transcript
RefSeq:NM_001128845.1 SMARCA4
RefSeq:NM_001128848.1 SMARCA4
RefSeq:NM_003072.3 SMARCA4
RefSeq:XM_017027165.1 SMARCA4
RefSeq:XM_017027168.1 SMARCA4
RefSeq:XM_017027167.1 SMARCA4
RefSeq:XM_017027166.1 SMARCA4
RefSeq:NM_001128847.1 SMARCA4
RefSeq:NM_001128844.1 SMARCA4
RefSeq:NM_001128846.1 SMARCA4
Other Identifiers
11740886_a_at
11742957_a_at
11742958_x_at
11742959_a_at
11754590_x_at
11756305_a_at
1569073_3p_x_at
1569073_PM_x_at
1569073_x_at
16858344
208793_PM_x_at
208793_x_at
208794_PM_s_at
208794_s_at
212520_PM_s_at
212520_s_at
213720_PM_s_at
213720_s_at
214360_3p_at
214360_PM_at
214360_at
214728_PM_x_at
214728_x_at
215714_PM_s_at
215714_s_at
32579_at
3820922
3820923
3820927
3820928
3820929
3820930
3820931
3820932
3820933
3820934
3820935
3820936
3820937
3820938
3820939
3820940
3820943
3820944
3820945
3820946
3820949
3820951
3820952
3820953
3820954
3820955
3820956
3820957
3820958
3820959
3820960
3820965
3820966
3820967
3820968
3820969
3820971
3820972
3820973
3820974
3820975
3820976
3820977
3820978
3820979
3820983
3820984
3820985
3820986
3820987
3820988
3820989
3820990
3820991
3820999
3821000
3821001
3821003
3821004
3821005
3821006
3821007
3821008
3821009
3821010
3821012
57257_s_at
6597
8025788
88069_s_at
A_14_P116631
A_14_P134129
A_23_P39034
A_23_P39040
A_24_P212851
D26156_s_at
GE59059
GE84765
GO:0000122
GO:0000776
GO:0000785
GO:0001164
GO:0001188
GO:0001221
GO:0001650
GO:0002039
GO:0003407
GO:0003677
GO:0003713
GO:0003714
GO:0003723
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006325
GO:0006337
GO:0006338
GO:0006355
GO:0006357
GO:0007399
GO:0008094
GO:0008284
GO:0016020
GO:0016363
GO:0016514
GO:0016586
GO:0016787
GO:0030071
GO:0030177
GO:0030308
GO:0030957
GO:0031492
GO:0032991
GO:0042393
GO:0043226
GO:0043923
GO:0045582
GO:0045596
GO:0045597
GO:0045663
GO:0045815
GO:0045892
GO:0045893
GO:0045944
GO:0048856
GO:0050681
GO:0051091
GO:0060090
GO:0060766
GO:0065003
GO:0070182
GO:0070316
GO:0071564
GO:0071565
GO:0120162
GO:0140092
GO:0140097
GO:0140110
GO:0140288
GO:0140657
GO:0140658
GO:1901838
GO:1902459
GO:1902661
GO:1902895
GO:2000045
GO:2000781
GO:2000819
HMNXSV003057489
Hs.78202.0.S1_3p_a_at
Hs.78202.1.S1_3p_a_at
Hs.78202.3.S1_3p_a_at
Hs.78202.3.S1_3p_at
Hs.78202.4.S1_3p_a_at
Hs.78202.5.S1_3p_a_at
Hs2.407212.1.S1_3p_at
Hs2.407212.1.S1_3p_x_at
ILMN_1814173
PH_hs_0004515
TC19000190.hg
U29175_at
Participates
as a component of
BRWD1:SMARCA4 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Homo sapiens)
MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm] (Homo sapiens)
POU3F1 gene:SOX10 dimer:HDAC2:SMARCA4 [nucleoplasm] (Homo sapiens)
as an input of
BRWD1 binds SMARCA4 (Homo sapiens)
Beta-catenin recruits SMARCA4 (Homo sapiens)
EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)
SOX10 dimer binds the POU3F1 promoter (Homo sapiens)
as a member of
SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)
Inferred To
SMARCA4 [nucleoplasm]
(Bos taurus)
SMARCA4 [nucleoplasm]
(Caenorhabditis elegans)
SMARCA4 [nucleoplasm]
(Canis familiaris)
SMARCA4 [nucleoplasm]
(Dictyostelium discoideum)
SMARCA4 [nucleoplasm]
(Drosophila melanogaster)
SMARCA4 [nucleoplasm]
(Gallus gallus)
SMARCA4 [nucleoplasm]
(Mus musculus)
SMARCA4 [nucleoplasm]
(Plasmodium falciparum)
SMARCA4 [nucleoplasm]
(Rattus norvegicus)
SMARCA4 [nucleoplasm]
(Saccharomyces cerevisiae)
SMARCA4 [nucleoplasm]
(Schizosaccharomyces pombe)
SMARCA4 [nucleoplasm]
(Sus scrofa)
smarca4 [nucleoplasm]
(Xenopus tropicalis)
smarca4a [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_003063.2
,
XP_016882655.1
,
NP_001122319.1
,
NP_001122318.1
,
NP_001122316.1
,
NP_001122320.1
,
XP_016882656.1
,
NP_001122317.1
,
XP_016882657.1
,
XP_016882654.1
Guide to Pharmacology - Targets
2740
OpenTargets
ENSG00000127616
ENSEMBL
ENST00000646510
,
ENSP00000494772
,
ENST00000643296
,
ENST00000646484
,
ENST00000590574
,
ENSP00000343896
,
ENST00000647230
,
ENST00000645460
,
ENSP00000494463
,
ENSP00000392837
,
ENSP00000494676
,
ENSP00000496635
,
ENST00000589677
,
ENST00000444061
,
ENST00000541122
,
ENST00000344626
,
ENSP00000466963
,
ENSP00000464778
,
ENST00000644737
,
ENSP00000495548
,
ENSP00000495536
,
ENSP00000445036
,
ENST00000429416
,
ENSP00000395654
HPA
ENSG00000127616-SMARCA4
ZINC - Substances
SMCA4_HUMAN
ZINC target
P51532
PRO
P51532
Pharos - Targets
P51532
GlyGen
P51532
Orphanet
SMARCA4
PDB
2GRC
,
6ZS2
,
2H60
,
5DKD
,
7VDV
,
5EA1
,
6HR2
,
3UVD
,
6LTH
,
8QJR
,
7VDT
,
7Y8R
,
7VRB
,
7TAB
,
8G1Q
,
8EB1
,
6BGH
,
6LTJ
,
6SY2
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12824 SMARCB1
1
SMARCB1 [nucleoplasm]
(R-HSA-389261)
0.953
39
UniProt:O14497 ARID1A
1
ARID1A [nucleoplasm]
(R-HSA-389259)
0.942
28
UniProt:Q92922 SMARCC1
1
SMARCC1 [nucleoplasm]
(R-HSA-389257)
0.934
29
UniProt:Q96GM5 SMARCD1
1
SMARCD1 [nucleoplasm]
(R-HSA-389255)
0.871
14
UniProt:Q8TAQ2 SMARCC2
1
SMARCC2 [nucleoplasm]
(R-HSA-389263)
0.837
20
UniProt:Q92785 DPF2
1
DPF2 [nucleoplasm]
(R-HSA-9727509)
0.837
15
UniProt:Q86U86 PBRM1
1
PBRM1 [nucleoplasm]
(R-HSA-389254)
0.802
7
UniProt:Q969G3 SMARCE1
1
SMARCE1 [nucleoplasm]
(R-HSA-389258)
0.788
8
UniProt:Q68CP9 ARID2
1
ARID2 [nucleoplasm]
(R-HSA-5225613)
0.767
10
UniProt:Q15532 SS18
1
SS18 [nucleoplasm]
(R-HSA-9727441)
0.758
24
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.742
8
UniProt:Q8NFD5 ARID1B
1
ARID1B [nucleoplasm]
(R-HSA-5225635)
0.723
5
UniProt:Q92784-2 DPF3
0.69
7
UniProt:O96019 ACTL6A
1
ACTL6A [nucleoplasm]
(R-HSA-2980912)
0.669
6
UniProt:Q8WUB8 PHF10
0.643
4
UniProt:Q92782 DPF1
1
DPF1 [nucleoplasm]
(R-HSA-8855001)
0.643
4
UniProt:A4PIV7 A4PIV7
0.637
14
UniProt:Q92784-1 DPF3
0.597
5
UniProt:Q9UHA2 S18L2
0.569
5
UniProt:Q969G3-2 SMARCE1
0.564
2
UniProt:O15360 FANCA
2
FANCA [cytosol]
(R-HSA-420796)
FANCA [nucleoplasm]
(R-HSA-419541)
0.543
3
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.537
9
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.527
2
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
3
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
3
UniProt:Q8WUZ0 BCL7C
1
BCL7C [nucleoplasm]
(R-HSA-9727457)
0.527
4
UniProt:Q4VC05 BCL7A
1
BCL7A [nucleoplasm]
(R-HSA-9727449)
0.527
3
UniProt:O14497-1 ARID1A
0.527
3
UniProt:Q92925 SMARCD2
1
SMARCD2 [nucleoplasm]
(R-HSA-5225626)
0.527
3
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.527
5
UniProt:Q12824-1 SMARCB1
0.527
4
UniProt:Q6STE5 SMARCD3
2
SMARCD3 [nucleoplasm]
(R-HSA-9727456)
SMARCD3 [nucleoplasm]
(R-HSA-400141)
0.527
2
UniProt:Q92784 DPF3
1
DPF3 [nucleoplasm]
(R-HSA-9727469)
0.527
3
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.524
2
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.512
3
UniProt:Q06330 RBPJ
1
RBPJ [nucleoplasm]
(R-HSA-3008668)
0.499
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.484
3
UniProt:Q9Y466 NR2E1
1
NR2E1 [nucleoplasm]
(R-HSA-376207)
0.484
4
UniProt:P04040 CAT
5
CAT [cytosol]
(R-HSA-9033141)
CAT [peroxisomal matrix]
(R-HSA-51417)
CAT [ficolin-1-rich granule lumen]
(R-HSA-6801279)
CAT [extracellular region]
(R-HSA-6806458)
CAT [secretory granule lumen]
(R-HSA-6801311)
0.483
2
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
5
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