Reactome | DVL1 [cytosol]

DVL1 [cytosol]

Stable Identifier

R-HSA-201687

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dvl-1

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Locations in the PathwayBrowser for interactor UniProt:Q9EQC9 Cxxc4

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External Reference Information

External Reference

UniProt:O14640 DVL1

Gene Names

DVL1

Chain

chain:1-695

Reference Genes

BioGPS Gene:1855 DVL1

COSMIC (genes):DVL1 DVL1

CTD Gene:1855 DVL1

dbSNP Gene:1855 DVL1

ENSEMBL:ENSG00000107404 DVL1

HGNC:3084 DVL1

KEGG:hsa:1855 DVL1

Monarch:1855 DVL1

NCBI Gene:1855 DVL1

OMIM:601365 DVL1

UCSC:O14640 DVL1

Reference Transcript

Participates

as a member of

DVL [cytosol] (Homo sapiens)

as an input of

DVL1 is bound by the HECT ubiquitin ligase HECW1 (Homo sapiens)

as a component of

DVL1:HECW1 [cytosol] (Homo sapiens)

as a candidate of

DVL [cytosol] (Homo sapiens)

Other forms of this molecule

pp-DVL1 [cytosol]

p-S-DVL1 [cytosol]

ub-DVL1 [cytosol]

Inferred To

Dvl1 [cytosol] (Mus musculus)

Dvl1 [cytosol] (Rattus norvegicus)

dsh [cytosol] (Drosophila melanogaster)

dsh-1 [cytosol] (Caenorhabditis elegans)

DVL1 [cytosol] (Bos taurus)

DVL1 [cytosol] (Canis familiaris)

DVL1 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000107404

ENSEMBL

ENSG00000107404, ENSP00000368169, ENSP00000368166, ENST00000378888, ENST00000378891

ZINC - Substances

DVL1_HUMAN

HPA

ENSG00000107404-DVL1

GeneCards

DVL1

ZINC target

O14640

PRO

O14640

Pharos - Targets

O14640

Orphanet

DVL1

PDB

6TTK, 6LCA, 6LCB

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O70239	5	Axin1 [cytosol] (R-RNO-4641133) phospho-Axin1 [cytosol] (R-RNO-3640864) phospho-Axin1 [cytosol] (R-RNO-3640841) phospho-Axin1 [cytosol] (R-RNO-206040) Axin1 [cytosol] (R-RNO-195249)	0.796	12
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.639	6
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.633	5
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.623	6
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.623	4
UniProt:Q9EQC9 Cxxc4	1	Cxxc4 [cytosol] (R-RNO-5368460)	0.611	5
UniProt:Q6P3W7 SCYL2			0.544	4
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.524	2
UniProt:O14640 DVL1	4	pp-DVL1 [cytosol] (R-HSA-3772396) p-S-DVL1 [cytosol] (R-HSA-201700) DVL1 [cytosol] (R-HSA-201687) ub-DVL1 [cytosol] (R-HSA-4641157)	0.524	2
UniProt:Q9Y4D1 DAAM1	1	DAAM1 [cytosol] (R-HSA-351052)	0.463	2
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.463	3

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