Reactome | CSNK2A1 [cytosol]

CSNK2A1 [cytosol]

Stable Identifier

R-HSA-201713

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase alpha subunit

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Mitophagy (Homo sapiens)
      - Receptor Mediated Mitophagy (Homo sapiens)
        
        FUNDC1 is phosphorylated by CK2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Condensation of Prometaphase Chromosomes (Homo sapiens)
        
        CK2 phosphorylates condensin I subunits (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - CK2 phosphorylates NFE2L2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Signal transduction by L1 (Homo sapiens)
        
        Phosphorylation of L1 by CK-II (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        pL1:CK-II [plasma membrane] (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - Synthesis of PC (Homo sapiens)
        
        Casein kinase II phosphorylates STARD10 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Protein folding (Homo sapiens)
  - Chaperonin-mediated protein folding (Homo sapiens)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
      - CK2 phosphorylates PDCL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN stability and activity (Homo sapiens)
        
        Casein kinase II phosphorylates PTEN (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - WNT mediated activation of DVL (Homo sapiens)
      - CSNK2-mediated phosphorylation of DVL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1 dimer [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68400 CSNK2A1

Gene Names

CSNK2A1, CK2A1

Chain

chain:1-391

Reference Genes

BioGPS Gene:1457 CSNK2A1

COSMIC (genes):CSNK2A1 CSNK2A1

CTD Gene:1457 CSNK2A1

dbSNP Gene:1457 CSNK2A1

ENSEMBL:ENSG00000101266 CSNK2A1

ENSEMBL:ENSG00000101266.19 CSNK2A1

HGNC:2457 CSNK2A1

KEGG Gene (Homo sapiens):1457 CSNK2A1

Monarch:1457 CSNK2A1

NCBI Gene:1457 CSNK2A1

OMIM:115440 CSNK2A1

UCSC:P68400 CSNK2A1

Reference Transcript

Other Identifiers

11733783_a_at

11740086_a_at

11740087_s_at

11762083_at

1457

1567014_PM_s_at

1567014_s_at

16916328

206075_PM_s_at

206075_s_at

212072_PM_s_at

212072_s_at

212073_PM_at

212073_at

212075_PM_s_at

212075_s_at

3363201

3363202

3363203

3363204

3363205

36235_at

3894222

3894223

3894225

3894227

3894229

3894230

3894231

3894232

3894233

3894234

3894235

3894236

3894237

3894238

3894240

3894243

3894245

3894247

3894251

3894254

3894257

3894259

3894264

3894268

3894269

3894273

3894281

3894282

40258_at

594_s_at

60425_at

79137_at

7946655

8064351

A_21_P0009995

A_23_P502575

A_24_P57324

GE56193

GE611140

GE85926

GO:0000166

GO:0000228

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0005886

GO:0005956

GO:0006457

GO:0006468

GO:0006915

GO:0007049

GO:0007059

GO:0007165

GO:0008284

GO:0012501

GO:0016055

GO:0016301

GO:0016310

GO:0016580

GO:0016581

GO:0016740

GO:0017148

GO:0018105

GO:0018107

GO:0023052

GO:0030163

GO:0030177

GO:0030307

GO:0031519

GO:0036211

GO:0042802

GO:0043154

GO:0043226

GO:0045182

GO:0045732

GO:0048511

GO:0050821

GO:0051879

GO:0061077

GO:0106310

GO:0140096

GO:1905818

GO:2000059

GO:2001234

HMNXSV003000295

HMNXSV003025661

HMNXSV003055623

Hs.155140.3.S1_3p_a_at

Hs.155140.3.S2_3p_at

Hs.155140.3.S3_3p_at

Hs2.406403.1.A1_3p_s_at

ILMN_1679501

ILMN_2386354

ILMN_2386355

M55265_at

PH_hs_0026100

TC11001423.hg

TC11003057.hg

TC20000542.hg

TC20001368.hg

TC20001369.hg

g4503094_3p_a_at

p21354

Participates

as a component of

Other forms of this molecule

CSNK2A1 [nucleoplasm]

Inferred To

CSNK2A1 [cytosol] (Bos taurus)

CSNK2A1 [cytosol] (Caenorhabditis elegans)

CSNK2A1 [cytosol] (Canis familiaris)

CSNK2A1 [cytosol] (Danio rerio)

CSNK2A1 [cytosol] (Dictyostelium discoideum)

CSNK2A1 [cytosol] (Drosophila melanogaster)

CSNK2A1 [cytosol] (Mus musculus)

CSNK2A1 [cytosol] (Plasmodium falciparum)

CSNK2A1 [cytosol] (Rattus norvegicus)

CSNK2A1 [cytosol] (Saccharomyces cerevisiae)

CSNK2A1 [cytosol] (Schizosaccharomyces pombe)

CSNK2A1 [cytosol] (Sus scrofa)

CSNK2A1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001886.1, NP_808227.1, NP_808228.1

ZINC - World Drugs

CSK21_HUMAN

Guide to Pharmacology - Targets

1549

OpenTargets

ENSG00000101266

ZINC - FDA approved

CSK21_HUMAN

ZINC - Substances

CSK21_HUMAN

ZINC target

P68400

ZINC - Biogenic

CSK21_HUMAN

PRO

P68400

PDB

3AMY, 7A4Q, 8BGC, 5ZN1, 7AY9, 5OSL, 7L1X, 4UBA, 5OUM, 3NSZ, 3Q9X, 4MD7, 5CQU, 3QA0, 6Z83, 5N9L, 5MO5, 5CU6, 5OSR, 5OTI, 6YPH, 5M4F, 5MOH, 3PE2, 6HOR, 3NGA, 5CVF, 5CTP, 6TLU, 5OTY, 6TLO, 6YUM, 7QGB, 6RFF, 7A49, 5OTQ, 5T1H, 5B0X, 6HME, 7X4H, 4FBX, 3AT4, 5VIE, 6HBN, 5OT5, 7BU4, 3H30, 8AEM, 3BQC, 5CSP, 6L1Z, 7Z39, 3TAX, 5CU3, 7ZYD, 6L23, 8AE7, 6RCB, 3PE4, 4DGL, 5CQW, 6FVF, 6EHU, 5OUU, 5ZN2, 6YUL, 5OT6, 5OMY, 3C13, 7AT5, 8AEC, 5MO8, 4GYY, 6TLR, 6EII, 6TEI, 4MD8, 8AEK, 5CVG, 6TLW, 5OTL, 5VIF, 5N9N, 3U4U, 1JWH, 3OWK, 3Q04, 6E37, 6YPJ, 3MB7, 3JUH, 5ONI, 6HOQ, 6YPK, 7QGC, 5OWH, 6RCM, 7AYA, 6TLP, 5OTR, 5OTO, 5MMF, 6SPW, 7A4B, 5OS7, 5ZN5, 3OWL, 2PVR, 5OTZ, 5NQC, 6Q38, 1PJK, 5CSV, 5CU4, 5ORK, 6Z19, 6QY7, 5OTD, 5MOD, 7ZY5, 6TLV, 6L22, 5MOW, 3Q9W, 7ZYK, 3AT3, 7ZYO, 5OS8, 6HOP, 3WIK, 4GZ3, 7QGD, 5H8G, 5MO6, 5OSZ, 6TLS, 6GIH, 7B8I, 7A4C, 5OSU, 3RPS, 6JWA, 3Q9Z, 6TLL, 3AT2, 3U87, 4GRB, 5CU0, 5MP8, 5OWL, 2ZJW, 5MOT, 3WAR, 6EHK, 6HOU, 5M4I, 4RLL, 5CS6, 5OTP, 5OUE, 5CVH, 6SPX, 7B8H, 7QGE, 5H8B, 3MB6, 5ZN3, 6HNY, 6RB1, 7PSU, 3OWJ, 4GYW, 6A1C, 4MD9, 3AXW, 5MO7, 7ZY0, 3WIL, 5OQU, 5ZN0, 5M44, 6YPN, 6YPG, 7ZYR, 4UB7, 5N9K, 4IB5, 3Q9Y, 5KU8, 5CLP, 3U9C, 5OTH, 6YZH, 5ORH, 6FVG, 5MPJ, 7ZY2, 4GUB, 6RFE, 5MOE, 5ZN4, 5CX9, 5OTS, 5OYF, 4NH1, 1NA7, 7QUX, 5CU2, 5M4C, 5HGV, 5OUL, 3PE1, 6HNW, 5MMR, 7ZY8, 5KWH, 5MOV, 5CSH, 6Z84, 3WOW, 6GMD, 6HOT, 3FWQ, 5N1V, 6L24, 6L21, 5ORJ, 6Q4Q, 5OSP, 4KWP, 3R0T, 5H8E, 3W8L, 5CT0

ZINC - Investigational

CSK21_HUMAN

ZINC - Metabolites

CSK21_HUMAN

GeneCards

P68400

HPA

ENSG00000101266-CSNK2A1

Ensembl

ENST00000646814, ENST00000400217, ENST00000646561, ENSP00000339247, ENSP00000495422, ENST00000647348, ENSP00000217244, ENST00000646305, ENST00000646477, ENST00000644003, ENSP00000495439, ENSP00000495912, ENSG00000101266, ENSP00000496569, ENSP00000495902, ENST00000217244, ENST00000643660, ENST00000645623, ENST00000349736, ENSP00000495248, ENSP00000495387, ENSP00000495998, ENSP00000383076

Pharos - Targets

P68400

ZINC - Predictions - Purchasable

CSK21_HUMAN

Orphanet

24441

HMDB Protein

HMDBP01433

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.801	6
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.77	5
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.688	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.688	3
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.666	4
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.59	2
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.59	2
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.589	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.589	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.571	2
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.564	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.564	2
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	5
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:P78563 ADARB1	1	ADARB1 [nucleoplasm] (R-HSA-62915)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.544	2
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.544	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.527	2

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