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CSNK2A2 [cytosol]
Stable Identifier
R-HSA-201721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Casein kinase alpha' subunit
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
Receptor Mediated Mitophagy (Homo sapiens)
FUNDC1 is phosphorylated by CK2 (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Condensation of Prometaphase Chromosomes (Homo sapiens)
CK2 phosphorylates condensin I subunits (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
CK2 phosphorylates NFE2L2 (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
Phosphorylation of L1 by CK-II (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
pL1:CK-II [plasma membrane] (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
CK2 phosphorylates nascent P (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Synthesis of PC (Homo sapiens)
Casein kinase II phosphorylates STARD10 (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
CK2 phosphorylates PDCL (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
Casein kinase II phosphorylates PTEN (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
CSNK2-mediated phosphorylation of DVL (Homo sapiens)
Casein kinase II [cytosol] (Homo sapiens)
CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
CSNK2A2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19784 CSNK2A2
Gene Names
CSNK2A2, CK2A2
Chain
chain:1-350
Reference Genes
BioGPS Gene:1459 CSNK2A2
COSMIC (genes):CSNK2A2 CSNK2A2
CTD Gene:1459 CSNK2A2
dbSNP Gene:1459 CSNK2A2
ENSEMBL:ENSG00000070770 CSNK2A2
ENSEMBL_homo_sapiens_GENE:ENSG00000070770.10 CSNK2A2
HGNC:2459 CSNK2A2
KEGG Gene (Homo sapiens):1459 CSNK2A2
Monarch:1459 CSNK2A2
NCBI Gene:1459 CSNK2A2
OMIM:115442 CSNK2A2
UCSC:P19784 CSNK2A2
Reference Transcript
RefSeq:NM_001896.2 CSNK2A2
Other Identifiers
11716807_a_at
1459
16826879
203575_PM_at
203575_at
3693534
3693547
3693549
3693550
3693552
3693553
3693555
3693556
3693561
3693564
3693567
3693569
3693571
3693572
3693573
37629_at
50900_at
8001666
A_23_P14915
GE57970
GO:0000166
GO:0000785
GO:0001669
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005956
GO:0006281
GO:0006302
GO:0006468
GO:0006886
GO:0006914
GO:0006915
GO:0007005
GO:0007049
GO:0007059
GO:0007283
GO:0012501
GO:0016055
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0021987
GO:0022414
GO:0023052
GO:0030163
GO:0031410
GO:0031519
GO:0036211
GO:0043226
GO:0048856
GO:0051726
GO:0097421
GO:0106310
GO:0140096
GO:1901524
GO:1903955
GO:1905818
GO:2000059
GO:2001234
HMNXSV003020620
ILMN_1723843
M55268_at
TC16001148.hg
g4503096_3p_at
Participates
as a component of
CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
CSNK2A2 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
CSNK2A2 [nucleoplasm]
Inferred To
CSNK2A2 [cytosol]
(Bos taurus)
CSNK2A2 [cytosol]
(Caenorhabditis elegans)
CSNK2A2 [cytosol]
(Canis familiaris)
CSNK2A2 [cytosol]
(Dictyostelium discoideum)
CSNK2A2 [cytosol]
(Drosophila melanogaster)
CSNK2A2 [cytosol]
(Mus musculus)
CSNK2A2 [cytosol]
(Plasmodium falciparum)
CSNK2A2 [cytosol]
(Rattus norvegicus)
CSNK2A2 [cytosol]
(Saccharomyces cerevisiae)
CSNK2A2 [cytosol]
(Schizosaccharomyces pombe)
CSNK2A2 [cytosol]
(Sus scrofa)
Homologues of CSNK2A2 [cytosol]
(Dictyostelium discoideum)
Homologues of CSNK2A2 [cytosol]
(Plasmodium falciparum)
Homologues of CSNK2A2 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001887.1
ZINC - World Drugs
CSK22_HUMAN
Guide to Pharmacology - Targets
1550
OpenTargets
ENSG00000070770
ZINC - FDA approved
CSK22_HUMAN
ZINC - Substances
CSK22_HUMAN
ZINC - Biogenic
CSK22_HUMAN
ZINC target
P19784
PRO
P19784
PDB
8Q77
,
7AT9
,
8QBU
,
3E3B
,
6L20
,
7A22
,
5Y9M
,
6HMB
,
5YF9
,
7A1Z
,
7XYH
,
5M4U
,
6HMD
,
6TEW
,
6TGU
,
6HMC
,
6QY9
,
5OOI
,
6QY8
,
8QCD
,
5M56
,
7ATV
,
8Q9S
,
8QCG
,
6HMQ
,
3OFM
,
7A2H
,
7A1B
,
6TE2
,
8QF1
,
3U87
,
5YWM
ZINC - Investigational
CSK22_HUMAN
IntEnz
2.7.11.1
GeneCards
P19784
HPA
ENSG00000070770-CSNK2A2
Ensembl
ENSG00000070770
,
ENSP00000262506
,
ENST00000262506
Pharos - Targets
P19784
ZINC - Predictions - Purchasable
CSK22_HUMAN
HMDB Protein
HMDBP01476
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.725
4
UniProt:Q8N5F7 NKAP
1
NKAP [nucleoplasm]
(R-HSA-9769602)
0.725
7
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.725
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.725
4
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.725
4
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
3
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.643
3
UniProt:P35659 DEK
1
DEK [nucleoplasm]
(R-HSA-5250643)
0.643
3
UniProt:Q9H2G4 TSPYL2
1
TSPYL2 [nucleoplasm]
(R-HSA-535540)
0.643
4
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.643
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
5
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.527
2
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
2
UniProt:O15541 RNF113A
1
RNF113A [nucleoplasm]
(R-HSA-9769563)
0.527
2
UniProt:Q2NL82 TSR1
2
TSR1 [nucleoplasm]
(R-HSA-6791574)
TSR1 [cytosol]
(R-HSA-6791570)
0.527
2
UniProt:P46100 ATRX
20
ATRX E288* [nucleoplasm]
(R-HSA-9670958)
ATRX K329Ifs*3 [nucleoplasm]
(R-HSA-9672232)
ATRX Q176* [nucleoplasm]
(R-HSA-9671592)
ATRX C268Qfs*18 [nucleoplasm]
(R-HSA-9672233)
ATRX Q177* [nucleoplasm]
(R-HSA-9671589)
ATRX K330Nfs*2 [nucleoplasm]
(R-HSA-9672231)
ATRX G161* [nucleoplasm]
(R-HSA-9671266)
ATRX Q176Hfs*13 [nucleoplasm]
(R-HSA-9671806)
ATRX R160Pfs*29 [nucleoplasm]
(R-HSA-9671801)
ATRX K319* [nucleoplasm]
(R-HSA-9671669)
ATRX W222* [nucleoplasm]
(R-HSA-9671670)
ATRX E63* [nucleoplasm]
(R-HSA-9670961)
ATRX S79* [nucleoplasm]
(R-HSA-9671244)
ATRX H166Mfs*4 [nucleoplasm]
(R-HSA-9672205)
ATRX Y266* [nucleoplasm]
(R-HSA-9671624)
ATRX L253* [nucleoplasm]
(R-HSA-9671688)
ATRX W263* [nucleoplasm]
(R-HSA-9671685)
ATRX Y187* [nucleoplasm]
(R-HSA-9671622)
ATRX Y204* [nucleoplasm]
(R-HSA-9671619)
ATRX Q292* [nucleoplasm]
(R-HSA-9671581)
0.527
2
UniProt:O15160 POLR1C
2
POLR1C [nucleoplasm]
(R-HSA-63498)
POLR1C [cytosol]
(R-HSA-1964454)
0.527
2
UniProt:Q99873 PRMT1
2
PRMT1 [cytosol]
(R-HSA-9632173)
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.527
2
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.527
2
UniProt:P16383 GCFC2
1
GCFC2 [nucleoplasm]
(R-HSA-8869311)
0.527
2
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.527
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.527
2
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.483
2
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