Reactome | CSNK2A2 [cytosol]

CSNK2A2 [cytosol]

Stable Identifier

R-HSA-201721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase alpha' subunit

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Mitophagy (Homo sapiens)
      - Receptor Mediated Mitophagy (Homo sapiens)
        
        FUNDC1 is phosphorylated by CK2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Condensation of Prometaphase Chromosomes (Homo sapiens)
        
        CK2 phosphorylates condensin I subunits (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - CK2 phosphorylates NFE2L2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Signal transduction by L1 (Homo sapiens)
        
        Phosphorylation of L1 by CK-II (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        pL1:CK-II [plasma membrane] (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - Synthesis of PC (Homo sapiens)
        
        Casein kinase II phosphorylates STARD10 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Protein folding (Homo sapiens)
  - Chaperonin-mediated protein folding (Homo sapiens)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
      - CK2 phosphorylates PDCL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN stability and activity (Homo sapiens)
        
        Casein kinase II phosphorylates PTEN (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - WNT mediated activation of DVL (Homo sapiens)
      - CSNK2-mediated phosphorylation of DVL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19784 CSNK2A2

Gene Names

CSNK2A2, CK2A2

Chain

chain:1-350

Reference Genes

BioGPS Gene:1459 CSNK2A2

COSMIC (genes):CSNK2A2 CSNK2A2

CTD Gene:1459 CSNK2A2

dbSNP Gene:1459 CSNK2A2

ENSEMBL:ENSG00000070770 CSNK2A2

ENSEMBL:ENSG00000070770.10 CSNK2A2

HGNC:2459 CSNK2A2

KEGG Gene (Homo sapiens):1459 CSNK2A2

Monarch:1459 CSNK2A2

NCBI Gene:1459 CSNK2A2

OMIM:115442 CSNK2A2

UCSC:P19784 CSNK2A2

Reference Transcript

RefSeq:NM_001896.2 CSNK2A2

Other Identifiers

11716807_a_at

1459

16826879

203575_PM_at

203575_at

3693534

3693547

3693549

3693550

3693552

3693553

3693555

3693556

3693561

3693564

3693567

3693569

3693571

3693572

3693573

37629_at

50900_at

8001666

A_23_P14915

GE57970

GO:0000166

GO:0000785

GO:0001669

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005956

GO:0006468

GO:0006886

GO:0006914

GO:0006915

GO:0007005

GO:0007049

GO:0007059

GO:0007283

GO:0012501

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0021987

GO:0022414

GO:0023052

GO:0030163

GO:0031410

GO:0031519

GO:0036211

GO:0043226

GO:0048856

GO:0051726

GO:0097421

GO:0106310

GO:0140096

GO:1903146

GO:1903955

GO:1905818

GO:2000059

GO:2001234

HMNXSV003020620

ILMN_1723843

M55268_at

TC16001148.hg

g4503096_3p_at

Participates

as a component of

Other forms of this molecule

CSNK2A2 [nucleoplasm]

Inferred To

CSNK2A2 [cytosol] (Bos taurus)

CSNK2A2 [cytosol] (Caenorhabditis elegans)

CSNK2A2 [cytosol] (Canis familiaris)

CSNK2A2 [cytosol] (Danio rerio)

CSNK2A2 [cytosol] (Dictyostelium discoideum)

CSNK2A2 [cytosol] (Drosophila melanogaster)

CSNK2A2 [cytosol] (Mus musculus)

CSNK2A2 [cytosol] (Plasmodium falciparum)

CSNK2A2 [cytosol] (Rattus norvegicus)

CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

CSNK2A2 [cytosol] (Schizosaccharomyces pombe)

CSNK2A2 [cytosol] (Sus scrofa)

CSNK2A2 [cytosol] (Xenopus tropicalis)

Homologues of CSNK2A2 [cytosol] (Dictyostelium discoideum)

Homologues of CSNK2A2 [cytosol] (Plasmodium falciparum)

Homologues of CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001887.1

ZINC - World Drugs

CSK22_HUMAN

Guide to Pharmacology - Targets

1550

OpenTargets

ENSG00000070770

ZINC - FDA approved

CSK22_HUMAN

ZINC - Substances

CSK22_HUMAN

ZINC target

P19784

ZINC - Biogenic

CSK22_HUMAN

PRO

P19784

PDB

7A1B, 3OFM, 7AT9, 6HMB, 7A2H, 6TE2, 5YWM, 3U87, 5M4U, 6QY9, 3E3B, 6TGU, 6TEW, 6HMQ, 7ATV, 5Y9M, 6L20, 5YF9, 7XYH, 6HMC, 5M56, 7A22, 5OOI, 6QY8, 7A1Z, 6HMD

ZINC - Investigational

CSK22_HUMAN

HPA

ENSG00000070770-CSNK2A2

GeneCards

P19784

Ensembl

ENSG00000070770, ENSP00000262506, ENST00000262506

Pharos - Targets

P19784

Orphanet

24442

ZINC - Predictions - Purchasable

CSK22_HUMAN

HMDB Protein

HMDBP01476

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.643	3
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.643	3
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.643	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	5
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	2