Reactome | PPP3CA [cytosol]

PPP3CA [cytosol]

Stable Identifier

R-HSA-201771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform, P2BA_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Calcineurin activates NFAT (Homo sapiens)
        
        Calcineurin binds NFATC1,2,3 (Homo sapiens)
        
        Calcineurin (CaN) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
        
        Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
        
        Activation of Calcineurin (Homo sapiens)
        
        Calcineurin (CaN) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        NFAT:CaN:CaM [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
        
        NFAT:CaN:CaM [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated Ca+2 mobilization (Homo sapiens)
      - Activation of Calcineurin (Homo sapiens)
        
        Calcineurin (CaN) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
      - Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
        
        NFAT:CaN:CaM [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)
      - Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
        
        NFAT:CaN:CaM [cytosol] (Homo sapiens)
        
        Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
        
        PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
        
        PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
        
        PPP3CA,B [cytosol] (Homo sapiens)
        
        PPP3CA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q08209 PPP3CA

Gene Names

PPP3CA, CALNA, CNA

Chain

initiator methionine:, chain:2-521

Reference Genes

BioGPS Gene:5530 PPP3CA

COSMIC (genes):PPP3CA PPP3CA

CTD Gene:5530 PPP3CA

dbSNP Gene:5530 PPP3CA

ENSEMBL:ENSG00000138814 PPP3CA

HGNC:9314 PPP3CA

KEGG:hsa:5530 PPP3CA

Monarch:5530 PPP3CA

NCBI Gene:5530 PPP3CA

OMIM:114105 PPP3CA

UCSC:Q08209 PPP3CA

Reference Transcript

Participates

as a member of

Other forms of this molecule

PPP3CA [nucleoplasm]

Inferred To

PPP3CA [cytosol] (Caenorhabditis elegans)

PPP3CA [cytosol] (Canis familiaris)

PPP3CA [cytosol] (Dictyostelium discoideum)

PPP3CA [cytosol] (Drosophila melanogaster)

PPP3CA [cytosol] (Gallus gallus)

PPP3CA [cytosol] (Plasmodium falciparum)

PPP3CA [cytosol] (Saccharomyces cerevisiae)

PPP3CA [cytosol] (Schizosaccharomyces pombe)

PPP3CA [cytosol] (Sus scrofa)

Ppp3ca [cytosol] (Mus musculus)

Ppp3ca [cytosol] (Rattus norvegicus)

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [cytosol] (Bos taurus)

Cross References

OpenTargets

ENSG00000138814

ENSEMBL

ENSP00000320580, ENSP00000422781, ENST00000394853, ENST00000512215, ENSP00000378322, ENSG00000138814, ENSP00000378323, ENST00000394854, ENST00000323055

HPA

ENSG00000138814-PPP3CA

GeneCards

PPP3CA

ZINC target

Q08209

PRO

Q08209

Pharos - Targets

Q08209

Orphanet

PPP3CA

GlyGen

Q08209

HMDB Protein

HMDBP07948

PDB

2R28, 2JZI, 6UUQ, 6NUF, 2W73, 1M63, 3LL8, 6NUC, 2JOG, 5SVE, 1MF8, 2P6B, 6NUU, 5C1V, 4F0Z, 9B9G, 1AUI, 4Q5U

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.678	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.483	2
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.463	3