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WAS [cytosol]
Stable Identifier
R-HSA-201879
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WASP
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
PI(4,5)P2:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)
PI(4,5)P2:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
NCK recruits WASP (Homo sapiens)
WAS [cytosol] (Homo sapiens)
p-SLP-76:NCK1:WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
Activation of WASP and N-WASP by CDC42 (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
WIP2:WASP complex [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
RHOJ:GTP:RHOJ effectors [plasma membrane] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
WIP2:WASP complex [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
WAS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42768 WAS
Gene Names
WAS, IMD2
Chain
initiator methionine:, chain:2-502
Reference Genes
BioGPS Gene:7454 WAS
COSMIC (genes):WAS WAS
CTD Gene:7454 WAS
dbSNP Gene:7454 WAS
ENSEMBL:ENSG00000015285 WAS
HGNC:12731 WAS
KEGG:hsa:7454 WAS
Monarch:7454 WAS
NCBI Gene:7454 WAS
OMIM:300392 WAS
UCSC:P42768 WAS
Reference Transcript
RefSeq:NM_000377.2 WAS
Other Identifiers
11721694_x_at
17103396
205400_PM_at
205400_at
38963_i_at
38964_PM_r_at
38964_r_at
3976767
3976768
3976769
3976770
3976772
3976773
3976774
3976775
3976776
3976777
3976779
3976780
3976781
3976783
3976784
3976785
3976786
3976787
3976788
3976789
3976790
3976791
3976792
3976793
3976794
3976795
3976796
64315_r_at
7454
8167334
A_14_P101264
A_23_P96331
GE88130
GO:0002376
GO:0002625
GO:0003779
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005911
GO:0006355
GO:0006952
GO:0006955
GO:0007010
GO:0007015
GO:0007596
GO:0008064
GO:0008092
GO:0008154
GO:0008544
GO:0010591
GO:0012506
GO:0015629
GO:0016192
GO:0016197
GO:0017124
GO:0019901
GO:0030036
GO:0030041
GO:0030048
GO:0030695
GO:0031267
GO:0031410
GO:0032488
GO:0035861
GO:0042110
GO:0042802
GO:0043226
GO:0043274
GO:0045335
GO:0045944
GO:0048856
GO:0051492
GO:0051497
GO:0065003
GO:0070062
GO:0071346
GO:0098772
GO:1905168
GO:2000146
HMNXSV003044475
ILMN_1760027
PH_hs_0000284
TC0X000257.hg
U12707_s_at
g4507908_3p_s_at
Participates
as a member of
WASP/N-WASP [cytosol] (Homo sapiens)
as a component of
p-SLP-76:NCK1:WASP [cytosol] (Homo sapiens)
as an input of
NCK recruits WASP (Homo sapiens)
Other forms of this molecule
p-Y291-WAS [cytosol]
Cross References
RefSeq
NP_000368.1
OpenTargets
ENSG00000015285
ENSEMBL
ENST00000698625
,
ENST00000376701
,
ENSP00000365891
,
ENSP00000513844
HPA
ENSG00000015285-WAS
PRO
P42768
Pharos - Targets
P42768
Orphanet
WAS
PDB
1T84
,
1EJ5
,
2K42
,
2A3Z
,
1CEE
,
2OT0
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.966
25
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.949
14
UniProt:P42768 WAS
2
p-Y291-WAS [cytosol]
(R-HSA-2197668)
WAS [cytosol]
(R-HSA-201879)
0.75
4
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.718
9
UniProt:P06241 FYN
6
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
0.696
4
UniProt:Q9P2A4 ABI3
0.666
4
UniProt:O15143 ARPC1B
1
ARPC1B [cytosol]
(R-HSA-6787770)
0.636
3
UniProt:P0DJ88 ESFU2
0.618
3
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.609
2
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.573
2
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.571
3
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.558
3
UniProt:Q92624 APBP2
0.556
3
UniProt:O94875 SRBS2
0.556
3
UniProt:P57075-2 UBASH3A
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:O43516-4 WIPF1
0.556
3
UniProt:P08103 Hck
4
p-Hck [cytosol]
(R-MMU-9676058)
phospho-p-HCK [cytosol]
(R-MMU-9676060)
Hck [cytosol]
(R-MMU-9609278)
HCK [cytosol]
(R-MMU-167708)
0.544
3
UniProt:P62999
6
RAC1 [endoplasmic reticulum membrane]
(R-CFA-5672076-2)
RAC1 [secretory granule membrane]
(R-CFA-6804770-2)
RAC1 [ficolin-1-rich granule membrane]
(R-CFA-6804802-2)
GGC-PalmC-RAC1 [plasma membrane]
(R-CFA-2316446-2)
RAC1 [cytosol]
(R-CFA-442615-2)
RAC1 [plasma membrane]
(R-CFA-351141-2)
0.469
2
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.463
3
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.463
2
UniProt:P11388 TOP2A
3
TOP2A [nucleoplasm]
(R-HSA-1362276)
polySUMO2,3-TOP2A [nucleoplasm]
(R-HSA-4641298)
monoSUMO1-K-TOP2A [nucleoplasm]
(R-HSA-4641367)
0.462
2
UniProt:Q02880-2 TOP2B
0.462
2
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