Reactome | TCF7L2 [nucleoplasm]

TCF7L2 [nucleoplasm]

Stable Identifier

R-HSA-201923

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TCF7L2 (TCF4), hTCF-4_1

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) transcription (Homo sapiens)
        
        CD274 Transcription (Homo sapiens)
        
        CTNNB1:CD274 gene [nucleoplasm] (Homo sapiens)
        
        TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
        
        TCF/LEF [nucleoplasm] (Homo sapiens)
        
        TCF7L2 [nucleoplasm] (Homo sapiens)
        
        TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
        
        TCF/LEF [nucleoplasm] (Homo sapiens)
        
        TCF7L2 [nucleoplasm] (Homo sapiens)
        
        CTNNB1 binding to CD274 gene (Homo sapiens)
        
        CTNNB1:CD274 gene [nucleoplasm] (Homo sapiens)
        
        TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
        
        TCF/LEF [nucleoplasm] (Homo sapiens)
        
        TCF7L2 [nucleoplasm] (Homo sapiens)
        
        TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
        
        TCF/LEF [nucleoplasm] (Homo sapiens)
        
        TCF7L2 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Peptide hormone metabolism (Homo sapiens)
  - Incretin synthesis, secretion, and inactivation (Homo sapiens)
    - Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
      - Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)
        
        hTCF-4:Beta-catenin [nucleoplasm] (Homo sapiens)
        
        hTCF-4 [nucleoplasm] (Homo sapiens)
        
        TCF7L2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NQB0 TCF7L2

Gene Names

TCF7L2, TCF4

Chain

chain:1-619

Reference Genes

COSMIC (genes):TCF4 TCF7L2

COSMIC (genes):TCF7L2 TCF7L2

dbSNP Gene:6934 TCF7L2

ENSEMBL:ENSG00000148737 TCF7L2

Participates

as a component of

TCF7L2:CTNNB1 [nucleoplasm] (Homo sapiens)

as a member of

as a candidate of

TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TCF7L2 K485fs*25 [nucleoplasm]

TCF7L2 R397W [nucleoplasm]

pT201,T212-TCF7L2 [nucleoplasm]

Inferred To

pan [nucleoplasm] (Drosophila melanogaster)

TCF7L2 [nucleoplasm] (Bos taurus)

TCF7L2 [nucleoplasm] (Canis familiaris)

TCF7L2 [nucleoplasm] (Gallus gallus)

TCF7L2 [nucleoplasm] (Sus scrofa)

Tcf7l2 [nucleoplasm] (Mus musculus)

Tcf7l2 [nucleoplasm] (Rattus norvegicus)

pop-1 [nucleoplasm] (Caenorhabditis elegans)

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.97	27
UniProt:Q13761 RUNX3	7	PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.656	14
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.612	7
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.61	6
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.597	6
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.543	5

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