Reactome | p-T309,S474-AKT2 [nucleoplasm]

p-T309,S474-AKT2 [nucleoplasm]

Stable Identifier

R-HSA-202087

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-AKT2 (T309, S474), RAC-beta serine/threonine protein kinase , RAC-PK-beta, Protein kinase Akt-2, Protein kinase B, beta, PKB beta

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External Reference Information

External Reference

UniProt:P31751 AKT2

Gene Names

AKT2

Chain

chain:1-481

Reference Genes

BioGPS Gene:208 AKT2

COSMIC (genes):AKT2 AKT2

CTD Gene:208 AKT2

dbSNP Gene:208 AKT2

ENSEMBL:ENSG00000105221 AKT2

HGNC:392 AKT2

KEGG:hsa:208 AKT2

Monarch:208 AKT2

NCBI Gene:208 AKT2

OMIM:164731 AKT2

UCSC:P31751 AKT2

Reference Transcript

Other Identifiers

11731469_at

11731470_at

11731471_a_at

11746138_s_at

11746139_a_at

11747947_a_at

11749525_a_at

11756698_a_at

11756699_x_at

11757813_x_at

11760277_at

11761086_x_at

1560689_3p_s_at

1560689_PM_s_at

1560689_s_at

2023_g_at

203809_PM_s_at

203809_s_at

208

211453_PM_s_at

211453_s_at

225471_PM_s_at

225471_s_at

226156_PM_at

226156_at

236664_PM_at

236664_at

3862470

3862472

3862473

3862474

3862475

3862476

3862477

3862478

3862479

3862480

3862481

3862482

3862483

3862484

3862485

3862486

3862487

3862488

3862489

3862490

3862491

3862492

3862493

3862494

3862495

3862496

3862497

3862498

3862499

3862500

3862501

3862502

3862503

3862504

3862505

3862506

3862507

3862508

3862509

3862510

3862511

3862512

3862513

3862514

3862515

3862516

3862521

3862522

3862523

3862526

3862527

3862528

3862530

3862544

3862545

40972_at

57350_at

75878_at

78734_s_at

8036840

87854_s_at

87856_r_at

87858_r_at

A_23_P208870

A_23_P373475

A_24_P359267

A_33_P3381647

A_33_P3400171

GE81047

GE86894

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005938

GO:0005975

GO:0005978

GO:0006006

GO:0006091

GO:0006417

GO:0006468

GO:0006915

GO:0007165

GO:0008286

GO:0010748

GO:0010907

GO:0012501

GO:0016740

GO:0030154

GO:0030334

GO:0030335

GO:0031410

GO:0032000

GO:0032287

GO:0032587

GO:0032869

GO:0035556

GO:0036211

GO:0043226

GO:0043231

GO:0045444

GO:0045725

GO:0046326

GO:0046872

GO:0050821

GO:0051726

GO:0060644

GO:0061024

GO:0071486

GO:0072659

GO:0090314

GO:0097473

GO:0098772

GO:0106310

GO:0140096

GO:0140677

GO:1903676

GO:2000147

HMNXSV003008065

Hs.182278.4.S1_3p_a_at

Hs.182278.5.S1_3p_at

Hs.326445.0.S1_3p_a_at

Hs.98325.0.A1_3p_at

Hs2.406970.1.S1_3p_at

Hs2.406970.1.S1_3p_x_at

ILMN_1743347

M95936_s_at

PH_hs_0016190

PH_hs_0035792

g337490_3p_a_at

Participates

as a member of

p-AKT1/2 [nucleoplasm] (Homo sapiens)

as a candidate of

p-T,p-S-AKT [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T309,S474-AKT2 [cytosol]

p-S474-AKT2 [plasma membrane]

AKT2 [plasma membrane]

AKT2 [cytosol]

p-T309-AKT2 [cytosol]

p-T309,S474-AKT2 [plasma membrane]

Inferred To

phospho-AKT2 [nucleoplasm] (Bos taurus)

Phospho-Akt2 [nucleoplasm] (Rattus norvegicus)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Danio rerio)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Mus musculus)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-T309,S474-AKT2 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of p-T309,S474-AKT2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of p-T309,S474-AKT2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of p-T309,S474-AKT2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of p-T309,S474-AKT2 [nucleoplasm] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-threonine at 309

Coordinate

309

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 474

Coordinate

474

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_011524921.1, XP_011524920.1, XP_016881959.1, XP_011524916.1, XP_011524922.1, NP_001617.1, XP_011524918.1, XP_011524917.1, NP_001317440.1

ZINC - World Drugs

AKT2_HUMAN

Guide to Pharmacology - Targets

1480

OpenTargets

ENSG00000105221

ENSEMBL

ENST00000392038, ENST00000311278, ENSP00000309428, ENSP00000375892, ENST00000424901, ENSP00000399532

ZINC - FDA approved

AKT2_HUMAN

ZINC - Substances

AKT2_HUMAN

ZINC - Biogenic

AKT2_HUMAN

ZINC target

P31751

PRO

P31751

GlyGen

P31751

PDB

1P6S, 1GZK, 2JDR, 2JDO, 1MRY, 1MRV, 2X39, 8Q61, 1O6K, 1O6L, 3E8D, 3E87, 2UW9, 3E88, 3D0E, 1GZO, 1GZN, 2XH5

ZINC - Investigational

AKT2_HUMAN

HPA

ENSG00000105221-AKT2

Pharos - Targets

P31751

Orphanet

AKT2

ZINC - Predictions - Purchasable

AKT2_HUMAN

HMDB Protein

HMDBP01319

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.641	3
UniProt:Q9C0C9 UBE2O	1	UBE2O [cytosol] (R-HSA-947641)	0.623	4
UniProt:P53804 TTC3			0.581	5
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:Q00526 CDK3			0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2

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