Reactome | NOS3 [cytosol]

NOS3 [cytosol]

Stable Identifier

R-HSA-202114

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nitric oxide synthase, endothelial, eNOS

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Locations in the PathwayBrowser for interactor UniProt:Q12891 HYAL2

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External Reference Information

External Reference

UniProt:P29474 NOS3

Gene Names

NOS3

Chain

initiator methionine:, chain:2-1203

Reference Genes

BioGPS Gene:4846 NOS3

COSMIC (genes):NOS3 NOS3

CTD Gene:4846 NOS3

dbSNP Gene:4846 NOS3

ENSEMBL:ENSG00000164867 NOS3

HGNC:7876 NOS3

KEGG:hsa:4846 NOS3

Monarch:4846 NOS3

NCBI Gene:4846 NOS3

UCSC:P29474 NOS3

Reference Transcript

Other Identifiers

11725467_a_at

11745591_a_at

17053455

1961_f_at

205581_3p_s_at

205581_PM_s_at

205581_s_at

3031714

3031716

3031717

3031720

3031721

3031722

3031723

3031724

3031725

3031726

3031727

3031728

3031729

3031730

3031731

3031732

3031733

3031734

3031735

3031736

3031737

3031738

3031740

3031741

3031742

3031743

3031744

3031745

3031746

3031747

3031748

3031749

3031750

3031751

3031752

3031753

4846

576_at

77168_at

8137280

85472_at

A_14_P136875

A_14_P138990

A_21_P0000025

A_23_P70849

A_33_P3305790

GE57703

GE58153

GO:0000139

GO:0001525

GO:0001542

GO:0001701

GO:0001974

GO:0002028

GO:0003012

GO:0003013

GO:0003057

GO:0003100

GO:0003180

GO:0003184

GO:0003203

GO:0003785

GO:0003824

GO:0004517

GO:0005515

GO:0005516

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005901

GO:0006520

GO:0006527

GO:0006809

GO:0006813

GO:0006816

GO:0007005

GO:0007263

GO:0008092

GO:0008217

GO:0008285

GO:0009408

GO:0009725

GO:0010181

GO:0010544

GO:0010628

GO:0014740

GO:0014806

GO:0016491

GO:0019430

GO:0020037

GO:0022414

GO:0030324

GO:0030666

GO:0031284

GO:0031644

GO:0031663

GO:0032496

GO:0034405

GO:0034617

GO:0034618

GO:0042311

GO:0043226

GO:0043267

GO:0043536

GO:0043542

GO:0045454

GO:0045747

GO:0045766

GO:0045776

GO:0046870

GO:0046872

GO:0048662

GO:0048856

GO:0048870

GO:0048873

GO:0050660

GO:0050661

GO:0050886

GO:0051649

GO:0051926

GO:0060412

GO:0070168

GO:0097110

GO:0097746

GO:0098754

GO:1902042

HMNXSV003009365

HMNXSV003039681

ILMN_1775224

M93718_at

PH_hs_0038843

TC07001009.hg

g10835160_3p_at

g10835160_3p_s_at

Participates

as a member of

NOS1,2,3 [cytosol] (Homo sapiens)

as an input of

N-myristoylation of eNOS (Homo sapiens)

Other forms of this molecule

2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]

2xPalmC-MyrG-NOS3 [plasma membrane]

2xPalmC-MyrG-NOS3 [Golgi membrane]

MyrG-NOS3 [cytosol]

MyrG-NOS3 [Golgi membrane]

2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]

2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]

2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]

Inferred To

NOS3 [cytosol] (Bos taurus)

NOS3 [cytosol] (Dictyostelium discoideum)

NOS3 [cytosol] (Drosophila melanogaster)

NOS3 [cytosol] (Gallus gallus)

NOS3 [cytosol] (Mus musculus)

NOS3 [cytosol] (Plasmodium falciparum)

NOS3 [cytosol] (Rattus norvegicus)

NOS3 [cytosol] (Saccharomyces cerevisiae)

NOS3 [cytosol] (Schizosaccharomyces pombe)

NOS3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001153581.1, NP_001153582.1, NP_001153583.1, NP_000594.2, XP_016867721.1

Guide to Pharmacology - Targets

1249

OpenTargets

ENSG00000164867

ENSEMBL

ENSP00000297494, ENSP00000420551, ENST00000467517, ENSP00000420215, ENST00000297494, ENST00000484524

HPA

ENSG00000164867-NOS3

ZINC target

P29474

PRO

P29474

Pharos - Targets

P29474

GlyGen

P29474

HMDB Protein

HMDBP00929

PDB

5VVB, 6CIF, 8UFT, 6CIE, 5XOF, 6NH6, 5UO8, 7TSH, 6PP2, 6PP0, 5VVD, 8UFU, 1NIW, 7TSM, 5UOC, 3EAH, 7TSO, 5UOB, 7TSG, 4D1P, 6NH4, 8FGP, 8FGR, 6NH5, 8FGT, 8FGQ, 6NH2, 1M9K, 1M9J, 6NH3, 2LL7, 1M9M, 6POV, 6AV7, 6AV6, 8UFR, 8UFS, 6NHF, 6NH7, 7TSI, 6PP4, 6PP3, 5VVC, 6PP1, 7UAO, 3NOS, 7TSK, 7M56, 7TSL, 5UOA, 5UO9, 7TSP, 7TSN, 8FGU, 6POZ, 6POY, 8FGN, 8FGO, 4D1O, 6POX, 1M9Q, 8FGS, 6POW, 2N8J, 6NH8, 2MG5, 6NH1, 1M9R, 6POU

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IVI9 NOSTRIN	2	NOSTRIN [endocytic vesicle membrane] (R-HSA-535014) NOSTRIN [plasma membrane] (R-HSA-202134)	0.729	9
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.582	4
UniProt:Q8IUI8 CRLF3			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
UniProt:Q9GZR2 REXO4			0.556	3
UniProt:O94851 MICA2			0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:A4FUJ8 A4FUJ8			0.556	3
UniProt:Q71DI3 H3C15	20	2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) Me1K5-HIST2H3A [nucleoplasm] (R-HSA-9677679) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803)	0.556	3
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.556	3
UniProt:Q8N6T3-3 ARFGAP1			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:Q9H347 UBQL3			0.556	3
UniProt:Q9NV79 PCMD2			0.556	3
UniProt:Q6X4W1-6 NSMF			0.556	3
UniProt:Q9BR01-2 Q9BR012			0.556	3
UniProt:P14079 TAX			0.556	3
IntAct:EBI-25831465 CCSB			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q9Y575-3 ASB3			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:P58304 VSX2			0.556	3
UniProt:Q8N594 MPND			0.556	3
UniProt:P57052 RBM11			0.556	3
UniProt:Q5T2W1 NHRF3			0.556	3
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q5SZD1 CF141			0.556	3
UniProt:P69905 HBA1	4	HBA1 [extracellular region] (R-HSA-2168862) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [cytosol] (R-HSA-1008268) CO-H+-HBA1 [cytosol] (R-HSA-1237026)	0.544	2
UniProt:Q92947 GCDH	1	GCDH [mitochondrial matrix] (R-HSA-71039)	0.524	3
UniProt:P50502 ST13	1	ST13 [cytosol] (R-HSA-5255410)	0.482	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.471	4

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