Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The glucuronate (GlcA) moiety of chondroitin sulfate (CS) can undergo C-5 epimerization to change into an iduronic acid (IdoA) moiety, thus changing the polymer composition and creating dermatan sulfate (DS). The GlcA of unsulfated chondroitin chains can also undergo this C-5 epimerization to produce dermatan. Dermatan-sulfate epimerase (DSE) mediates these reactions (Tiedemann et al. 2001). More recently, a single homologue of DSE, dermatan sulfate epimerase-like (DSEL), has been determined to possess epimerase activity (Pacheco et al. 2009). DSEL is genetically associated with type II bipolar disorder (Goossens et al. 2003).
Literature References
PubMed ID Title Journal Year
11414686 The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis

Larsson, T, Tiedemann, K, Malmström, A, Heinegård, D

Arch Biochem Biophys 2001
19188366 Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate

Pacheco, B, Malmström, A, Maccarana, M

J. Biol. Chem. 2009
16505484 Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2

Aebersold, R, Maccarana, M, Li, JP, Malmström, J, Tiedemann, K, Olander, B, Malmström, A, Lindahl, U

J Biol Chem 2006
12556911 A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder

Backhovens, H, Claes, S, Van Broeckhoven, C, Van den Bossche, D, Mendlewicz, J, Van Gestel, S, Massat, I, De Rijk, P, Del-Favero, J, Goossens, D, Souery, D

Mol. Psychiatry 2003
Catalyst Activity

chondroitin-glucuronate 5-epimerase activity of DSE,DSEL [Golgi membrane]

Orthologous Events
Cite Us!