DSPG and CSPG translocate to the lysosome for degradation

Stable Identifier
R-HSA-2022056
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, lysosomal lumen
ReviewStatus
5/5
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DSPG and CSPG translocate to the lysosome for degradation
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As part of the natural turnover of GAGs, extracellular KSPGs translocate to the lysosome to be degraded. The translocation process is unsure but could be either endocytosis from outside the cell or autophagy from inside the cell (Winchester 2005).
Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
Participants
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Output
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as an event of
Orthologous Events
DSPG and CSPG translocate to the lysosome for degradation (Bos taurus)
DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)
DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)
DSPG and CSPG translocate to the lysosome for degradation (Drosophila melanogaster)
DSPG and CSPG translocate to the lysosome for degradation (Gallus gallus)
DSPG and CSPG translocate to the lysosome for degradation (Mus musculus)
DSPG and CSPG translocate to the lysosome for degradation (Rattus norvegicus)
DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)
DSPG and CSPG translocate to the lysosome for degradation (Xenopus tropicalis)
Authored
Jassal, B  (2011-11-25)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-11-25)
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