Reactome | CHST14 transfers SO4(2-) to GalNAc in dermatan or DS

CHST14 transfers SO4(2-) to GalNAc in dermatan or DS

Stable Identifier

R-HSA-2022063

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

GalNAc is sulfated on position 4 of GalNAc in dermatan or dermatan sulfate

ReviewStatus

5/5

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CHST14 transfers SO4(2-) to GalNAc in dermatan or DS

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Important functional domains in dermatan or dermatan sulfate (DS) are generated by the action of an epimerase (which converts D-glucuronic acid into its epimer L-iduronic acid) together with 4-O-sulfation. These domains are named 4-O-sulfated iduronic acid blocks (Pachebo et al. 2009). Carbohydrate sulfotransferase 14 (CHST14) (Evers et al. 2001) mediates the transfer of sulfate to position 4 of another N-acetylgalactosamine (GalNAc) residue of D2,4(S)2-PG (sulfated on position 2 of IdoA and position 4 of GalNAc) to produce a further sulfated product D2,4,4(S)3-PG (sulfated on another GalNAc in addition to the ones above).

Literature References

PubMed ID	Title	Journal	Year
19661164	Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate Pacheco, B, Maccarana, M, Malmström, A	Glycobiology	2009
11470797	Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase Baenziger, JU, Schachner, M, Kang, HG, Evers, MR, Xia, G	J. Biol. Chem.	2001