Reactome | PDPK1 [cytosol]

PDPK1 [cytosol]

Stable Identifier

R-HSA-202210

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PDK1, 3-phosphoinositide dependent protein kinase-1

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External Reference Information

External Reference

UniProt:O15530 PDPK1

Gene Names

PDPK1, PDK1

Chain

chain:1-556

Reference Genes

BioGPS Gene:5170 PDPK1

COSMIC (genes):PDPK1 PDPK1

CTD Gene:5170 PDPK1

dbSNP Gene:5170 PDPK1

ENSEMBL:ENSG00000140992 PDPK1

ENSEMBL_homo_sapiens_GENE:ENSG00000140992.19 PDPK1

HGNC:8816 PDPK1

KEGG Gene (Homo sapiens):5170 PDPK1

Monarch:5170 PDPK1

NCBI Gene:5170 PDPK1

OMIM:605213 PDPK1

UCSC:O15530 PDPK1

Reference Transcript

Other Identifiers

11719708_a_at

11719709_x_at

11719710_a_at

11719711_a_at

11756248_a_at

16823153

204524_PM_at

204524_at

224986_PM_s_at

224986_s_at

32029_PM_at

32029_at

3644975

3644985

3644987

3644988

3644989

3644991

3644997

3645000

3645001

3645002

3645004

3645005

3645006

3645007

3645008

3645009

3645010

3645011

3645012

3645013

3645014

3645015

3645016

3645017

3645018

3645022

3645099

3645101

3645102

3645103

3645104

3645117

3645211

3645215

3645216

3645217

3645252

3676981

3676982

3676983

3676985

3676994

3676996

3676998

3676999

3677000

3677049

3677050

3677051

3677054

3677064

3677066

3677073

3677075

3677076

4864258_3p_at

4864258_3p_x_at

5170

64052_at

73168_s_at

77710_at

7992670

7992678

7998825

A_14_P120883

A_14_P123854

A_14_P128757

A_23_P66219

A_24_P222599

A_24_P830690

GE54148

GO:0000166

GO:0002376

GO:0003323

GO:0003824

GO:0004672

GO:0004674

GO:0004676

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005925

GO:0006468

GO:0006469

GO:0006972

GO:0007010

GO:0007155

GO:0007173

GO:0008286

GO:0010518

GO:0010594

GO:0010667

GO:0012501

GO:0014069

GO:0016004

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018107

GO:0019722

GO:0023052

GO:0030036

GO:0030154

GO:0030512

GO:0031295

GO:0031410

GO:0032148

GO:0032869

GO:0034122

GO:0035556

GO:0036211

GO:0042995

GO:0043122

GO:0043226

GO:0043274

GO:0043304

GO:0043536

GO:0045766

GO:0046777

GO:0048009

GO:0048856

GO:0048870

GO:0051281

GO:0051897

GO:0055065

GO:0055085

GO:0070161

GO:0071364

GO:0072659

GO:0097191

GO:0098542

GO:0098772

GO:0106310

GO:0140096

GO:1903078

GO:1903672

GO:1905564

GO:2000352

HMNXSV003019159

HMNXSV003046190

HMNXSV003046750

Hs.25063.1.S1_3p_at

ILMN_1653793

ILMN_1773174

ILMN_1773758

ILMN_1810554

ILMN_2387799

PH_hs_0009318

PH_hs_0035616

TC16000787.hg

TC16001386.hg

g4505694_3p_at

g4505694_3p_s_at

Participates

as an input of

Other forms of this molecule

p-S241-PDPK1 [cytosol]

PDPK1 [plasma membrane]

Inferred To

PDPK1 [cytosol] (Bos taurus)

PDPK1 [cytosol] (Caenorhabditis elegans)

PDPK1 [cytosol] (Canis familiaris)

PDPK1 [cytosol] (Danio rerio)

PDPK1 [cytosol] (Dictyostelium discoideum)

PDPK1 [cytosol] (Drosophila melanogaster)

PDPK1 [cytosol] (Gallus gallus)

PDPK1 [cytosol] (Mus musculus)

PDPK1 [cytosol] (Plasmodium falciparum)

PDPK1 [cytosol] (Rattus norvegicus)

PDPK1 [cytosol] (Saccharomyces cerevisiae)

PDPK1 [cytosol] (Schizosaccharomyces pombe)

PDPK1 [cytosol] (Sus scrofa)

PDPK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_112558.2, NP_001248745.1, NP_002604.1

ZINC - World Drugs

PDPK1_HUMAN

Guide to Pharmacology - Targets

1519

OpenTargets

ENSG00000140992

ZINC - FDA approved

PDPK1_HUMAN

ZINC - Substances

PDPK1_HUMAN

ZINC target

O15530

ZINC - Biogenic

PDPK1_HUMAN

PRO

O15530

PDB

3QC4, 1Z5M, 1H1W, 1OKZ, 3IOP, 5HO7, 5HNG, 5LVL, 3HRF, 3HRC, 3H9O, 5LVM, 3NUY, 4RQV, 1UU9, 3ION, 3QCQ, 1UU7, 5HKM, 4A07, 3QD4, 4RRV, 5LVP, 3RWQ, 4A06, 4CT2, 3QD3, 3RCJ, 3RWP, 4CT1, 8DQT, 2XCH, 2PE1, 3QCY, 4XX9, 3QD0, 1W1H, 2PE0, 3QCX, 2VKI, 1OKY, 5HO8, 1W1G, 2R7B, 3QCS, 1UU8, 1W1D, 1UVR, 5LVN, 3NUU, 5LVO, 3NAY, 3NAX, 3OTU, 3ORZ, 3NUS, 4RQK, 4AW1, 3ORX, 5ACK, 4AW0, 1UU3, 5MRD, 3NUN, 3SC1, 6WJQ, 3PWY, 2XCK, 2PE2, 2BIY

ZINC - Investigational

PDPK1_HUMAN

ZINC - Metabolites

PDPK1_HUMAN

GeneCards

O15530

HPA

ENSG00000140992-PDPK1

Ensembl

ENST00000268673, ENST00000441549, ENSG00000140992, ENSP00000268673, ENST00000342085, ENSP00000344220, ENSP00000395357

Pharos - Targets

O15530

ZINC - Predictions - Purchasable

PDPK1_HUMAN

HMDB Protein

HMDBP01430

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.767	4
UniProt:Q9Y4P3 TBL2			0.623	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.564	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.544	3
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.527	3
UniProt:Q92896 GLG1	1	GLG1 [plasma membrane] (R-HSA-2870220)	0.527	3
UniProt:P31431 SDC4	20	SDC4 [lysosomal lumen] (R-HSA-2090041) HS(6)-SDC4 [lysosomal lumen] (R-HSA-2090058) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(6)-SDC4 [Golgi lumen] (R-HSA-2076330) HS(5)-SDC4 [Golgi lumen] (R-HSA-2076510) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) SDC4 [Golgi lumen] (R-HSA-2054111) XylS-SDC4 [Golgi lumen] (R-HSA-2064195) HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674)	0.527	3
UniProt:O75116 ROCK2	2	ROCK2 [cytosol] (R-HSA-419058) Activated ROCK2 [cytosol] (R-HSA-4687775)	0.527	2
UniProt:Q6A1A2 PDPK2			0.527	3
UniProt:O75487 GPC4	20	GPC4 [lysosomal lumen] (R-HSA-2090030) HS(6)-GPC4 [lysosomal lumen] (R-HSA-2090073) HS(1)-GPC4 [Golgi lumen] (R-HSA-2076401) HS(2)-GPC4 [Golgi lumen] (R-HSA-2076336) HS(3)-GPC4 [Golgi lumen] (R-HSA-2076439) HS(4)-GPC4 [Golgi lumen] (R-HSA-2076368) HS(6)-GPC4 [Golgi lumen] (R-HSA-2076538) HS(5)-GPC4 [Golgi lumen] (R-HSA-2076488) Heparan-GPC4 [Golgi lumen] (R-HSA-2076475) Heparan(1)-GPC4 [Golgi lumen] (R-HSA-2076560) Heparan(2)-GPC4 [Golgi lumen] (R-HSA-2076555) Heparan(4)-GPC4 [Golgi lumen] (R-HSA-2076440) HS(4)-GPC4 [plasma membrane] (R-HSA-2076638) HS(6)-GPC4 [plasma membrane] (R-HSA-2076677) HS(2)-GPC4 [plasma membrane] (R-HSA-2076662) HS(1)-GPC4 [plasma membrane] (R-HSA-2076673) HS(3)-GPC4 [plasma membrane] (R-HSA-2076697) HS(5)-GPC4 [plasma membrane] (R-HSA-2076658) Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064030) GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064215)	0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	3
UniProt:Q9BZF1 OSBPL8	1	OSBPL8 [cytosol] (R-HSA-8867870)	0.527	2
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.527	3
UniProt:P35052 GPC1	20	GPC1 [lysosomal lumen] (R-HSA-2090044) HS(6)-GPC1 [lysosomal lumen] (R-HSA-2090035) HS(1)-GPC1 [Golgi lumen] (R-HSA-2076424) HS(2)-GPC1 [Golgi lumen] (R-HSA-2076296) HS(3)-GPC1 [Golgi lumen] (R-HSA-2076340) HS(4)-GPC1 [Golgi lumen] (R-HSA-2076502) HS(6)-GPC1 [Golgi lumen] (R-HSA-2076531) HS(5)-GPC1 [Golgi lumen] (R-HSA-2076288) Heparan-GPC1 [Golgi lumen] (R-HSA-2076567) Heparan(1)-GPC1 [Golgi lumen] (R-HSA-2076476) Heparan(2)-GPC1 [Golgi lumen] (R-HSA-2076501) Heparan(4)-GPC1 [Golgi lumen] (R-HSA-2076605) Heparan(3)-GPC1 [Golgi lumen] (R-HSA-2076503) GPC1 [Golgi lumen] (R-HSA-2054106) HS(4)-GPC1 [plasma membrane] (R-HSA-2076668) HS(6)-GPC1 [plasma membrane] (R-HSA-2076629) HS(2)-GPC1 [plasma membrane] (R-HSA-2076632) HS(1)-GPC1 [plasma membrane] (R-HSA-2076645) HS(3)-GPC1 [plasma membrane] (R-HSA-2076636) HS(5)-GPC1 [plasma membrane] (R-HSA-2076648)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	4
UniProt:P18827 SDC1	20	SDC1 [plasma membrane] (R-HSA-174758) SDC1 [lysosomal lumen] (R-HSA-2090025) HS(6)-SDC1 [lysosomal lumen] (R-HSA-2090082) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) Heparan-SDC1 [Golgi lumen] (R-HSA-2076561) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) SDC1 [Golgi lumen] (R-HSA-2054105) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666)	0.527	3
UniProt:O00468 AGRN	20	AGRN(30-2045) [lysosomal lumen] (R-HSA-2090057) HS(6)-AGRN [lysosomal lumen] (R-HSA-2090081) HS(1)-AGRN [Golgi lumen] (R-HSA-2076350) HS(2)-AGRN [Golgi lumen] (R-HSA-2076521) HS(3)-AGRN [Golgi lumen] (R-HSA-2076493) HS(4)-AGRN [Golgi lumen] (R-HSA-2076337) HS(6)-AGRN [Golgi lumen] (R-HSA-2076568) HS(5)-AGRN [Golgi lumen] (R-HSA-2076606) Heparan-AGRN [Golgi lumen] (R-HSA-2076530) Heparan(1)-AGRN [Golgi lumen] (R-HSA-2076317) Heparan(2)-AGRN [Golgi lumen] (R-HSA-2076301) Heparan(4)-AGRN [Golgi lumen] (R-HSA-2076300) Heparan(3)-AGRN [Golgi lumen] (R-HSA-2076569) AGRN(30-2045) [Golgi lumen] (R-HSA-2054104) XylS-AGRN(30-2045) [Golgi lumen] (R-HSA-2064220) Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064130) HS(4)-AGRN [plasma membrane] (R-HSA-2076654) HS(6)-AGRN [plasma membrane] (R-HSA-2076678) HS(2)-AGRN [plasma membrane] (R-HSA-2076686) HS(1)-AGRN [plasma membrane] (R-HSA-2076634)	0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) SDC2 [Golgi lumen] (R-HSA-2054101) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.527	2
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.527	2
UniProt:Q00005 2ABB			0.524	8
UniProt:O95704 APBB3			0.488	2
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.488	2

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