Reactome | LOXL2(26-?) [extracellular region]

LOXL2(26-?) [extracellular region]

Stable Identifier

R-HSA-2022106

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

LOXL2 propeptide, Lysyl oxidase homolog 2, LOXL2_HUMAN, LOXL2

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
    - Crosslinking of collagen fibrils (Homo sapiens)
      - Prolysyl oxidase activation (Homo sapiens)
        
        Lysyl oxidase propeptides [extracellular region] (Homo sapiens)
        
        LOXL2(26-?) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y4K0 LOXL2

Gene Names

LOXL2

Chain

signal peptide:1-25, chain:26-774

Reference Genes

BioGPS Gene:4017 LOXL2

COSMIC (genes):LOXL2 LOXL2

CTD Gene:4017 LOXL2

dbSNP Gene:4017 LOXL2

ENSEMBL:ENSG00000134013 LOXL2

HGNC:6666 LOXL2

Monarch:4017 LOXL2

NCBI Gene:4017 LOXL2

OMIM:606663 LOXL2

UCSC:Q9Y4K0 LOXL2

Reference Transcript

RefSeq:NM_002318.2 LOXL2

Other Identifiers

11718832_a_at

11718833_a_at

11718834_at

11751288_a_at

17075478

17075529

202997_PM_s_at

202997_s_at

202998_PM_s_at

202998_s_at

202999_PM_s_at

202999_s_at

3127819

3127820

3127821

3127822

3127823

3127826

3127828

3127829

3127831

3127832

3127833

3127834

3127835

3127836

3127837

3127838

3127844

3127845

3127846

3127847

3127848

3127851

3127852

3127861

3127862

3127863

3127865

3127866

3127867

3127868

3127869

3127870

3127871

3127873

3127874

3127875

3127876

3127877

3127918

33127_at

4017

8149774

A_23_P111995

GE59532

GO:0000122

GO:0000785

GO:0001666

GO:0001837

GO:0001935

GO:0002040

GO:0003824

GO:0004720

GO:0005507

GO:0005509

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005783

GO:0006325

GO:0006355

GO:0010718

GO:0016020

GO:0016491

GO:0016641

GO:0018057

GO:0030154

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0032332

GO:0036211

GO:0043226

GO:0043542

GO:0045892

GO:0046688

GO:0046872

GO:0048870

GO:0062023

GO:0070492

GO:0070828

GO:0140096

GO:1902455

HMNXSV003004254

Hs.83354.0.A1_3p_a_at

ILMN_1656802

PH_hs_0004760

TC08002613.hg

U89942_at

g4505010_3p_a_at

g4959424_3p_a_at

Participates

as a candidate of

Lysyl oxidase propeptides [extracellular region] (Homo sapiens)

Other forms of this molecule

LOXL2 [extracellular region]

LOXL2(?-774) [extracellular region]

Inferred To

LOXL2(26-?) [extracellular region] (Bos taurus)

LOXL2(26-?) [extracellular region] (Danio rerio)

LOXL2(26-?) [extracellular region] (Mus musculus)

LOXL2(26-?) [extracellular region] (Rattus norvegicus)

Loxl2 [extracellular region] (Drosophila melanogaster)

LOXL2 [extracellular region] (Canis familiaris)

LOXL2 [extracellular region] (Gallus gallus)

LOXL2 [extracellular region] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2853

ENSEMBL

ENSP00000373783, ENST00000389131

OpenTargets

ENSG00000134013

IntEnz

1.4.3.13

HPA

ENSG00000134013-LOXL2

PRO

Q9Y4K0

Pharos - Targets

Q9Y4K0

HMDB Protein

HMDBP08250

PDB

5ZE3

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.602	6
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	3
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.527	2
UniProt:P02751 FN1	10	FN1(32-2386) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620)	0.506	2

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