Reactome | LOXL4 [extracellular region]

LOXL4 [extracellular region]

Stable Identifier

R-HSA-2022127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

proLOXL4, Lysyl oxidase homolog 4, LOXL4_HUMAN

Locations in the PathwayBrowser

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Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
    - Crosslinking of collagen fibrils (Homo sapiens)
      - Prolysyl oxidase activation (Homo sapiens)
        
        Prolysyl oxidases [extracellular region] (Homo sapiens)
        
        LOXL4 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96JB6 LOXL4

Gene Names

LOXL4, LOXC

Chain

signal peptide:1-24, chain:25-756

Reference Genes

BioGPS Gene:84171 LOXL4

COSMIC (genes):LOXL4 LOXL4

CTD Gene:84171 LOXL4

dbSNP Gene:84171 LOXL4

ENSEMBL:ENSG00000138131 LOXL4

HGNC:17171 LOXL4

KEGG Gene (Homo sapiens):84171 LOXL4

Monarch:84171 LOXL4

NCBI Gene:84171 LOXL4

OMIM:607318 LOXL4

UCSC:Q96JB6 LOXL4

Reference Transcript

RefSeq:NM_032211.6 LOXL4

Other Identifiers

0006220176

11727440_at

11727441_at

16717272

227145_at

3302694

3302695

3302696

3302697

3302698

3302699

3302700

3302703

3302704

3302706

3302709

3302710

3302711

3302713

3302714

3302715

3302716

3302717

3302718

3302719

3302721

62213_at

7935553

84171

A_23_P12755

A_24_P406754

GE87704

GO:0003674

GO:0004720

GO:0005044

GO:0005507

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006464

GO:0006810

GO:0006897

GO:0008150

GO:0016020

GO:0016192

GO:0016491

GO:0016641

GO:0018057

GO:0018215

GO:0030198

GO:0030199

GO:0032991

GO:0043167

GO:0043226

GO:0043235

GO:0046872

GO:0055114

GO:0070062

HMNXSV003007901

Hs.306814.0.S1_3p_at

ILMN_1754174

ILMN_2179083

PH_hs_0015787

TC10001576.hg

Participates

as a candidate of

Prolysyl oxidases [extracellular region] (Homo sapiens)

Other forms of this molecule

LOXL4(25-?) [extracellular region]

LOXL4(?-756) [extracellular region]

Inferred To

Homologues of LOXL4 [extracellular region] (Drosophila melanogaster)

Loxl2 [extracellular region] (Drosophila melanogaster)

Loxl4 [extracellular region] (Mus musculus)

Loxl4 [extracellular region] (Rattus norvegicus)

loxl4 [extracellular region] (Danio rerio)

Loxl1 [extracellular region] (Drosophila melanogaster)

LOXL4 [extracellular region] (Canis familiaris)

LOXL4 [extracellular region] (Gallus gallus)

LOXL4 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_115587.6

OpenTargets

ENSG00000138131

GeneCards

Q96JB6

HPA

ENSG00000138131-LOXL4

Ensembl

ENSP00000260702, ENSG00000138131, ENST00000260702

PRO

Q96JB6

Pharos - Targets

Q96JB6

GlyGen

Q96JB6

HMDB Protein

HMDBP08252

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14957 GRIN2C	3	p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P55212 CASP6	5	CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P06396 GSN	7	GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2

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