Reactome | p-Y188,Y199-CD3E [plasma membrane]

p-Y188,Y199-CD3E [plasma membrane]

Stable Identifier

R-HSA-202228

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD3 epsilon with phosphorylated ITAM

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Generation of second messenger molecules (Homo sapiens)
      - Phosphorylation of PLC-gamma1 (Homo sapiens)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
      - Phosphorylation of SLP-76 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
      - Phosphorylation of TBSMs in LAT (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
    - Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
      - Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
    - Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
      - Activation of ZAP-70 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
      - PTPN22 dephosphorylates ZAP70 (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
      - Phosphorylation of ZAP-70 by Lck (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 delta with phosphorylated ITAMs [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)
        
        CD3 epsilon: CD3 gamma with phosphorylated ITAM [plasma membrane] (Homo sapiens)
        
        p-Y188,Y199-CD3E [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07766 CD3E

Gene Names

CD3E, T3E

Chain

signal peptide:1-22, chain:23-207

Reference Genes

BioGPS Gene:916 CD3E

COSMIC (genes):CD3E CD3E

CTD Gene:916 CD3E

dbSNP Gene:916 CD3E

ENSEMBL:ENSG00000198851 CD3E

HGNC:1674 CD3E

KEGG:hsa:916 CD3E

Monarch:916 CD3E

NCBI Gene:916 CD3E

OMIM:186830 CD3E

UCSC:P07766 CD3E

Reference Transcript

RefSeq:NM_000733.3 CD3E

Other Identifiers

11729855_at

11761574_a_at

16731795

205456_PM_at

205456_at

3351284

3351285

3351286

3351287

3351288

3351289

3351290

3351291

3351292

3351293

3351294

3351295

3351296

3351297

36277_at

7944179

916

A_14_P117535

A_23_P416747

A_24_P86968

GE60506

GO:0001772

GO:0001954

GO:0002250

GO:0002376

GO:0002669

GO:0002870

GO:0004888

GO:0005515

GO:0005783

GO:0005794

GO:0005886

GO:0005911

GO:0007166

GO:0007169

GO:0007172

GO:0007186

GO:0007224

GO:0009897

GO:0010628

GO:0010629

GO:0016020

GO:0016358

GO:0017124

GO:0019722

GO:0019901

GO:0021549

GO:0030159

GO:0031295

GO:0032729

GO:0032743

GO:0032753

GO:0033634

GO:0035739

GO:0042098

GO:0042101

GO:0042102

GO:0042105

GO:0042106

GO:0042110

GO:0042608

GO:0042802

GO:0042981

GO:0043197

GO:0043226

GO:0044297

GO:0045059

GO:0045060

GO:0045879

GO:0046629

GO:0046631

GO:0046649

GO:0048856

GO:0050731

GO:0050850

GO:0050852

GO:0050870

GO:0060089

GO:0060090

GO:0065003

GO:0097190

GO:2000563

HMNXSV003040023

ILMN_1739794

M23323_s_at

PH_hs_0000378

TC11001060.hg

g4502670_3p_at

Participates

as a component of

Other forms of this molecule

CD3E [plasma membrane]

Inferred To

phospho-CD3E [plasma membrane] (Bos taurus)

phospho-CD3E [plasma membrane] (Canis familiaris)

phospho-CD3E [plasma membrane] (Sus scrofa)

phospho-p-Y188,Y199-CD3E [plasma membrane] (Gallus gallus)

phospho-Cd3e [plasma membrane] (Mus musculus)

phospho-Cd3e [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 188

Coordinate

188

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 199

Coordinate

199

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_000724.1

Guide to Pharmacology - Targets

2742

OpenTargets

ENSG00000198851

ENSEMBL

ENSP00000354566, ENST00000361763

HPA

ENSG00000198851-CD3E

PRO

P07766

Pharos - Targets

P07766

Orphanet

CD3E

GlyGen

P07766

PDB

8WYI, 8WXE, 8YC0, 8JCB, 7FJF, 1A81, 5QU2, 8ES9, 8ES7, 8F0L, 7PHR, 8ES8, 7FJD, 7FJE, 1XIW, 1SY6, 2ROL, 8JC0, 6JXR, 8WY0

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.737	6
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.675	4
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.597	6
UniProt:P43403 ZAP70	3	p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252) p-Y493-ZAP70 [cytosol] (R-HSA-202368) ZAP70 [cytosol] (R-HSA-202397)	0.527	3

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