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AGT(35-41) [extracellular region]
Stable Identifier
R-HSA-2022354
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Angiotensin-(2-8), Angiotensin III, ANG2-8, ANGT_HUMAN, AGT
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) (Homo sapiens)
AGT(35-41) [extracellular region] (Homo sapiens)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)
AGT(35-41) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01019 AGT
Gene Names
AGT, SERPINA8
Chain
signal peptide:1-24, chain:25-476, peptide:25-34, peptide:25-33, peptide:25-32, peptide:25-31, peptide:25-29, peptide:25-28, peptide:26-32, peptide:27-32
Reference Genes
BioGPS Gene:183 AGT
COSMIC (genes):AGT AGT
CTD Gene:183 AGT
dbSNP Gene:183 AGT
ENSEMBL:ENSG00000135744 AGT
ENSEMBL_homo_sapiens_GENE:ENSG00000135744.9 AGT
HGNC:333 AGT
Monarch:183 AGT
NCBI Gene:183 AGT
OMIM:106150 AGT
UCSC:P01019 AGT
Reference Transcript
RefSeq:NM_000029.3 AGT
Other Identifiers
11730726_s_at
11749833_s_at
16700385
183
202834_PM_at
202834_at
2460290
2460291
2460293
2460295
2460297
2460298
2460299
2460300
2460301
2460302
2460305
2460307
2460308
2460309
684_at
7924987
A_23_P115261
GE80879
GO:0001558
GO:0001819
GO:0001822
GO:0001974
GO:0002016
GO:0002018
GO:0002019
GO:0002034
GO:0003012
GO:0003013
GO:0003014
GO:0003081
GO:0004867
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0006351
GO:0006355
GO:0006954
GO:0007186
GO:0007199
GO:0007200
GO:0007263
GO:0007267
GO:0008083
GO:0008217
GO:0010536
GO:0010595
GO:0010613
GO:0010718
GO:0010744
GO:0012501
GO:0014873
GO:0019229
GO:0023052
GO:0030154
GO:0030198
GO:0030312
GO:0031012
GO:0031702
GO:0031703
GO:0033864
GO:0034330
GO:0034374
GO:0035813
GO:0036211
GO:0038166
GO:0042127
GO:0042310
GO:0042981
GO:0043226
GO:0043407
GO:0045742
GO:0045893
GO:0048018
GO:0048146
GO:0048856
GO:0048870
GO:0050729
GO:0050886
GO:0051092
GO:0051247
GO:0051387
GO:0051897
GO:0055065
GO:0061098
GO:0062023
GO:0070062
GO:0072562
GO:0090190
GO:0097746
GO:0098772
GO:1901201
GO:1901203
GO:1901394
GO:1902895
GO:1903598
GO:1903779
GO:1905920
GO:1990776
GO:2000379
GO:2001238
HMNXSV003046508
ILMN_1813530
K02215_at
PH_hs_0022023
TC01006281.hg
g4557286_3p_at
Participates
as an input of
ANPEP hydrolyzes Angiotensin III to Angiotensin IV (Oryctolagus cuniculus)
ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8) (Homo sapiens)
as an output of
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)
Other forms of this molecule
AGT(36-41) [extracellular region]
AGT(34-40) [extracellular region]
AGT(34-42) [extracellular region]
AGT [extracellular region]
AGT(34-43) [extracellular region]
AGT(34-41) [extracellular region]
Inferred To
Spn42Da [extracellular region]
(Drosophila melanogaster)
Agt [extracellular region]
(Mus musculus)
Agt [extracellular region]
(Rattus norvegicus)
srp-6 [extracellular region]
(Caenorhabditis elegans)
Spn28Da [extracellular region]
(Drosophila melanogaster)
AGT [extracellular region]
(Bos taurus)
AGT [extracellular region]
(Canis familiaris)
AGT [extracellular region]
(Sus scrofa)
Spn88Eb [extracellular region]
(Drosophila melanogaster)
Spn27A [extracellular region]
(Drosophila melanogaster)
srp-2 [extracellular region]
(Caenorhabditis elegans)
Acp76A [extracellular region]
(Drosophila melanogaster)
Spn100A [extracellular region]
(Drosophila melanogaster)
Spn42Dd [extracellular region]
(Drosophila melanogaster)
srp-8 [extracellular region]
(Caenorhabditis elegans)
Spn43Aa [extracellular region]
(Drosophila melanogaster)
Spn47C [extracellular region]
(Drosophila melanogaster)
Dmel\CG43366 [extracellular region]
(Drosophila melanogaster)
srp-7 [extracellular region]
(Caenorhabditis elegans)
Spn42Db [extracellular region]
(Drosophila melanogaster)
Spn75F [extracellular region]
(Drosophila melanogaster)
Homologues of AGT(35-41) [extracellular region]
(Caenorhabditis elegans)
Homologues of AGT(35-41) [extracellular region]
(Drosophila melanogaster)
Spn28Db [extracellular region]
(Drosophila melanogaster)
Spn55B [extracellular region]
(Drosophila melanogaster)
AGT(35-41) [extracellular region]
(Caenorhabditis elegans)
AGT(35-41) [extracellular region]
(Gallus gallus)
nec [extracellular region]
(Drosophila melanogaster)
Spn31A [extracellular region]
(Drosophila melanogaster)
Spn43Ab [extracellular region]
(Drosophila melanogaster)
Spn53F [extracellular region]
(Drosophila melanogaster)
Spn88Ea [extracellular region]
(Drosophila melanogaster)
srp-1 [extracellular region]
(Caenorhabditis elegans)
Spn38F [extracellular region]
(Drosophila melanogaster)
agt [extracellular region]
(Danio rerio)
agt [extracellular region]
(Xenopus tropicalis)
srp-3 [extracellular region]
(Caenorhabditis elegans)
Spn42Dc [extracellular region]
(Drosophila melanogaster)
Spn42De [extracellular region]
(Drosophila melanogaster)
Spn28B [extracellular region]
(Drosophila melanogaster)
Spn85F [extracellular region]
(Drosophila melanogaster)
Spn28F [extracellular region]
(Drosophila melanogaster)
Spn43Ad [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000020.1
OpenTargets
ENSG00000135744
HPA
ENSG00000135744-AGT
GeneCards
P01019
Ensembl
ENSP00000505963
,
ENSP00000505985
,
ENSG00000135744
,
ENSP00000505063
,
ENSP00000355627
,
ENST00000680041
,
ENST00000366667
,
ENST00000681269
,
ENST00000679738
,
ENST00000681514
,
ENSP00000504866
PRO
P01019
Pharos - Targets
P01019
Orphanet
15475
HMDB Protein
HMDBP02609
PDB
2JP8
,
5M3X
,
3WOO
,
6I3I
,
5E2Q
,
2X0B
,
7C6A
,
5M3Y
,
1N9U
,
4FYS
,
6OS0
,
4AA1
,
2WXW
,
3CK0
,
3WOR
,
6JOD
,
1N9V
,
6I3F
,
4APH
,
5XJM
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q10714
2
ACE(30-1306) [plasma membrane]
(R-DME-508496-2)
ACE(30-1232) [extracellular region]
(R-DME-2065414-2)
0.558
2
UniProt:P00797 REN
3
REN [plasma membrane]
(R-HSA-2022352)
REN(24-406) [plasma membrane]
(R-HSA-2065391)
REN [extracellular region]
(R-HSA-2022343)
0.558
2
UniProt:Q9UI10 EIF2B4
1
EIF2B4 [cytosol]
(R-HSA-72521)
0.556
3
UniProt:Q9UMY4 SNX12
0.556
3
UniProt:O43493-5 O434935
0.556
3
UniProt:Q8N0U8 VKORC1L1
1
VKORC1L1 [endoplasmic reticulum membrane]
(R-HSA-2980944)
0.556
3
UniProt:C9J082 C9J082
0.556
3
UniProt:O00746 NME4
1
NME4 [mitochondrial inner membrane]
(R-HSA-60026)
0.556
3
UniProt:Q8IYM2 SLN12
0.556
3
UniProt:CCDC26 A0A024R9H7
0.556
3
UniProt:Q8NFB2 T185A
0.556
3
UniProt:Q8TAS3 Q8TAS3
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.527
2
UniProt:O95167 NDUFA3
1
NDUFA3 [mitochondrial inner membrane]
(R-HSA-60180)
0.527
2
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
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