ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Stable Identifier
R-HSA-2022378
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
ACE2(18-805):Zn2+ Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
ReviewStatus
5/5
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ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)
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Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).
Literature References
PubMed ID Title Journal Year
11815627 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

Gavin, J, Vickers, C, Nichols, A, Acton, S, Patane, M, Godbout, K, Kaushik, V, Hales, P, Tang, J, Hsieh, F, Parsons, T, Tummino, P, Baronas, E, Dick, L

J Biol Chem 2002
15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

Hooper, NM, Turner, AJ, Grant, PJ, Thomas, DA, Rice, GI

Biochem J 2004
10924499 A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

Turner, AJ, Hooper, NM, Karran, E, Hyde, R, Christie, G, Tipnis, SR

J Biol Chem 2000
10969042 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

Godbout, K, Breitbart, RE, Gosselin, M, Donovan, M, Robison, K, Jeyaseelan, R, Stagliano, N, Acton, S, Hsieh, F, Donoghue, M, Woolf, B, Baronas, E

Circ Res 2000
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

metallocarboxypeptidase activity of ACE2(18-805):Zn2+ dimer [plasma membrane]

Physical Entity
ACE2(18-805):Zn2+ dimer [plasma membrane] (Homo sapiens)
Activity
metallocarboxypeptidase activity (GO:0004181)
Orthologous Events
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Bos taurus)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Gallus gallus)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Xenopus tropicalis)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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