Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes angiotensin-(1-10) (AGT(34-43), angiotensin I) directly to angiotensin-(1-7) (Rice et al. 2004). MME is the major enzyme involved in the metabolic inactivation of a number of bioactive signaling peptides including the enkephalins, substance P, endothelin, bradykinin, atrial natriuretic factor, and the incretin hormone glucagon-like peptide 1. MME requires zinc as cofactor (Oefner et al. 2004, Oefner et al. 2007).
Fournie-Zaluski, MC, Roques, BP, Dale, GE, Oefner, C
Dale, GE, Oefner, C, Pierau, S, Schulz, H
Hooper, NM, Turner, AJ, Grant, PJ, Thomas, DA, Rice, GI
metallopeptidase activity of MME:Zn2+ [plasma membrane]
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