Chondroitin sulfate biosynthesis

Stable Identifier
R-HSA-2022870
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Chondroitin sulfate biosynthesis
Click the image above or here to open this pathway in the Pathway Browser
Chondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS molecule (Pavao et al. 2006, Silbert & Sugumaran 2002).
Literature References
PubMed ID Title Journal Year
17239764 Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches

Mourão, PA, Pavão, MS, Vilela-Silva, AC

Adv Pharmacol 2006
12512856 Biosynthesis of chondroitin/dermatan sulfate

Sugumaran, G, Silbert, JE

IUBMB Life 2002
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
chondroitin sulfate biosynthetic process (0030206)
Orthologous Events
Chondroitin sulfate biosynthesis (Bos taurus)
Chondroitin sulfate biosynthesis (Canis familiaris)
Chondroitin sulfate biosynthesis (Danio rerio)
Chondroitin sulfate biosynthesis (Drosophila melanogaster)
Chondroitin sulfate biosynthesis (Gallus gallus)
Chondroitin sulfate biosynthesis (Mus musculus)
Chondroitin sulfate biosynthesis (Rattus norvegicus)
Chondroitin sulfate biosynthesis (Sus scrofa)
Chondroitin sulfate biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-01)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-01)
Cite Us!