Reactome | ITK [cytosol]

ITK [cytosol]

Stable Identifier

R-HSA-202319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase ITK/TSK

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Locations in the PathwayBrowser for interactor UniProt:Q13094 LCP2

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External Reference Information

External Reference

UniProt:Q08881 ITK

Gene Names

ITK, EMT, LYK

Chain

chain:1-620

Reference Genes

BioGPS Gene:3702 ITK

COSMIC (genes):ITK ITK

CTD Gene:3702 ITK

dbSNP Gene:3702 ITK

ENSEMBL:ENSG00000113263 ITK

ENSEMBL_homo_sapiens_GENE:ENSG00000113263.14 ITK

HGNC:6171 ITK

KEGG Gene (Homo sapiens):3702 ITK

Monarch:3702 ITK

NCBI Gene:3702 ITK

OMIM:186973 ITK

UCSC:Q08881 ITK

Reference Transcript

RefSeq:NM_005546.3 ITK

Other Identifiers

11737866_s_at

11754649_s_at

1478_at

1479_g_at

16991497

211339_PM_s_at

211339_s_at

2837233

2837234

2837235

2837239

2837240

2837242

2837246

2837248

2837249

2837251

2837255

2837256

2837257

2837258

2837259

2837261

2837262

2837263

2837264

2837265

3702

8109507

A_14_P134958

A_23_P354146

A_23_P354151

D13720_s_at

GE86210

GO:0000166

GO:0001819

GO:0001865

GO:0002250

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006968

GO:0007165

GO:0007202

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0035556

GO:0036211

GO:0042110

GO:0043226

GO:0046629

GO:0046872

GO:0048856

GO:0050852

GO:0050853

GO:0140096

HMNXSV003038591

ILMN_1699160

L10717_at

PH_hs_0012267

TC05000865.hg

g399657_3p_a_at

Participates

as a member of

TEC,BTK,ITK,(TXK) [cytosol] (Homo sapiens)

as an input of

Recruitment of ITK to SLP-76 (Homo sapiens)

as a component of

ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y180,Y512-ITK [cytosol]

p-Y512-ITK [cytosol]

Inferred To

Itk [cytosol] (Rattus norvegicus)

ITK [cytosol] (Bos taurus)

ITK [cytosol] (Canis familiaris)

ITK [cytosol] (Danio rerio)

ITK [cytosol] (Drosophila melanogaster)

ITK [cytosol] (Mus musculus)

ITK [cytosol] (Sus scrofa)

ITK [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005537.3

ZINC - World Drugs

ITK_HUMAN

Guide to Pharmacology - Targets

2046

OpenTargets

ENSG00000113263

ZINC - FDA approved

ITK_HUMAN

ZINC - Substances

ITK_HUMAN

ZINC target

Q08881

ZINC - Biogenic

ITK_HUMAN

PRO

Q08881

PDB

3T9T, 3V5J, 4MF1, 4PP9, 4PQN, 2YUQ, 1SNX, 3V8W, 3QGY, 4M14, 4M15, 4L7S, 3V5L, 4MF0, 4RFM, 4HCV, 3MIY, 3MJ2, 4QD6, 4M12, 4M0Y, 3MJ1, 4M0Z, 4M13, 2E6I, 1SNU, 4PPA, 3QGW, 3V8T, 4HCT, 1SM2, 4PPB, 2LMJ, 4KIO, 4HCU, 4PPC

ZINC - Investigational

ITK_HUMAN

HPA

ENSG00000113263-ITK

GeneCards

Q08881

Ensembl

ENST00000422843, ENSP00000398655, ENSG00000113263

Pharos - Targets

Q08881

ZINC - Predictions - Purchasable

ITK_HUMAN

Orphanet

19494

HMDB Protein

HMDBP01487

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.734	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.669	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.643	3
UniProt:P10686 Plcg1	8	p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) PLCG1 [cytosol] (R-RNO-202320) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.59	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.564	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.544	3
UniProt:O14556 GAPDHS	2	Unfolded GAPDHS [cytosol] (R-HSA-6813805) GAPDHS [cytosol] (R-HSA-372873)	0.527	2
UniProt:Q58FG0 HS905			0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2

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