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Recruitment of Gads to LAT
Stable Identifier
R-HSA-202325
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Recruitment of Gads to LAT (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Gads is a member of the Grb2 family containing SH2 and SH3 domains with the arrangement SH3-SH2-SH3. Gads binds to the tyrosine phosphorylated residues Y171 and Y191 of LAT through its SH2 domain. It plays a critical role in signaling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT.
Literature References
PubMed ID
Title
Journal
Year
11607830
The role of Gads in hematopoietic cell signalling
Liu, SK
,
McGlade, CJ
,
Berry, DM
Oncogene
2001
Participants
Input
GRAP2 [cytosol]
(Homo sapiens)
p-5Y-LAT [plasma membrane]
(Homo sapiens)
Output
GADS:p-5Y-LAT [plasma membrane]
(Homo sapiens)
Participates
as an event of
Generation of second messenger molecules (Homo sapiens)
Orthologous Events
Recruitment of Gads to LAT (Bos taurus)
Recruitment of Gads to LAT (Canis familiaris)
Recruitment of Gads to LAT (Mus musculus)
Recruitment of Gads to LAT (Rattus norvegicus)
Recruitment of Gads to LAT (Sus scrofa)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-10-29)
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