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p-5Y-LAT [plasma membrane]
Stable Identifier
R-HSA-202364
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Disassociation of PLC-gamma1 from LAT (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
phosphorylated PLC-gamma1 bound to LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Homo sapiens)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
PLCG1:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Homo sapiens)
phosphorylated PLC-gamma1 bound to LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
SLP-76 bound to Gads:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Recruitment of Gads to LAT (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Recruitment of ITK to SLP-76 (Homo sapiens)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Recruitment of PLC-gamma1 to LAT (Homo sapiens)
PLCG1:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
Recruitment of SLP-76 to Gads (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
SLP-76 bound to Gads:LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
p-5Y-LAT [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43561 LAT
Gene Names
LAT
Chain
chain:1-262
Reference Genes
BioGPS Gene:27040 LAT
COSMIC (genes):LAT LAT
CTD Gene:27040 LAT
dbSNP Gene:27040 LAT
ENSEMBL:ENSG00000213658 LAT
ENSEMBL_homo_sapiens_GENE:ENSG00000213658.13 LAT
HGNC:18874 LAT
KEGG Gene (Homo sapiens):27040 LAT
Monarch:27040 LAT
NCBI Gene:27040 LAT
OMIM:602354 LAT
UCSC:O43561 LAT
Reference Transcript
RefSeq:NM_001014987.1 LAT
RefSeq:NM_001014989.1 LAT
RefSeq:NM_014387.3 LAT
RefSeq:NM_001014988.1 LAT
Other Identifiers
11726777_a_at
11743748_a_at
16817537
209881_PM_s_at
209881_s_at
211005_PM_at
211005_at
27040
3654964
3654965
3654966
3654967
3654969
3654970
3654972
3654974
3654975
3654976
3654977
3654978
3654981
3654983
3654984
3654985
3654986
3654987
40688_at
7994535
7994541
A_23_P44105
A_23_P44112
GE55241
GE81922
GO:0001772
GO:0002250
GO:0002260
GO:0002376
GO:0005515
GO:0005634
GO:0005794
GO:0005886
GO:0005911
GO:0006954
GO:0006955
GO:0007165
GO:0007229
GO:0007265
GO:0008180
GO:0010467
GO:0016020
GO:0016192
GO:0019722
GO:0019901
GO:0023052
GO:0030159
GO:0035556
GO:0036211
GO:0042110
GO:0043226
GO:0043303
GO:0045121
GO:0045860
GO:0048872
GO:0050852
GO:0050863
GO:0060090
HMNXSV003017433
ILMN_1691539
ILMN_1750188
ILMN_2281320
ILMN_2404625
PH_hs_0026523
PH_hs_0034136
g2828023_3p_a_at
g2828025_3p_at
p33449
p33450
Participates
as an output of
Disassociation of PLC-gamma1 from LAT (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
as an input of
Recruitment of PLC-gamma1 to LAT (Homo sapiens)
Recruitment of Gads to LAT (Homo sapiens)
as a component of
phosphorylated PLC-gamma1 bound to LAT [plasma membrane] (Homo sapiens)
PLCG1:p-5Y-LAT [plasma membrane] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y200,Y220-LAT [plasma membrane]
LAT [plasma membrane]
Inferred To
phospho-LAT [plasma membrane]
(Bos taurus)
phospho-LAT [plasma membrane]
(Canis familiaris)
phospho-LAT [plasma membrane]
(Sus scrofa)
Ghost homologue of p-5Y-LAT [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of p-5Y-LAT [plasma membrane]
(Gallus gallus)
Ghost homologue of p-5Y-LAT [plasma membrane]
(Xenopus tropicalis)
phospho-Lat [plasma membrane]
(Mus musculus)
phospho-Lat [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 161
Coordinate
161
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 200
Coordinate
200
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 220
Coordinate
220
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 255
Coordinate
255
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 156
Coordinate
156
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001014989.2
,
NP_001014988.1
,
NP_001014987.1
,
NP_055202.1
OpenTargets
ENSG00000213658
HPA
ENSG00000213658-LAT
GeneCards
O43561
Ensembl
ENST00000564277
,
ENSP00000398793
,
ENSP00000354119
,
ENSP00000456761
,
ENSP00000457036
,
ENST00000360872
,
ENSG00000213658
,
ENST00000454369
,
ENST00000566177
,
ENSP00000378845
,
ENSP00000378841
,
ENST00000395456
,
ENST00000395461
PRO
O43561
Pharos - Targets
O43561
Orphanet
26797
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.81
7
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.708
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.591
3
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
3
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.525
2
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
4
UniProt:Q8N1K5 THMS1
0.462
2
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