Reactome | GRAP2 [cytosol]

GRAP2 [cytosol]

Stable Identifier

R-HSA-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GADS, GRB2-related adapter protein 2

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Locations in the PathwayBrowser for interactor UniProt:P13646 KRT13

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External Reference Information

External Reference

UniProt:O75791 GRAP2

Gene Names

GRAP2, GADS, GRB2L, GRID

Chain

chain:1-330

Reference Genes

BioGPS Gene:9402 GRAP2

COSMIC (genes):GRAP2 GRAP2

CTD Gene:9402 GRAP2

dbSNP Gene:9402 GRAP2

ENSEMBL:ENSG00000100351 GRAP2

HGNC:4563 GRAP2

KEGG:hsa:9402 GRAP2

Monarch:9402 GRAP2

NCBI Gene:9402 GRAP2

OMIM:604518 GRAP2

UCSC:O75791 GRAP2

Reference Transcript

Other Identifiers

11750488_a_at

11752952_a_at

16930348

16930368

208406_PM_s_at

208406_s_at

38865_at

38866_at

38867_g_at

3946100

3946105

3946109

3946110

3946111

3946112

3946114

3946116

3946124

3946125

3946126

3946127

3946128

3946129

3946131

3946132

3946133

3946134

3946135

3946136

3946137

66212_at

8073194

9402

A_23_P143720

A_24_P10884

A_24_P408449

GE81443

GO:0001784

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007165

GO:0007265

GO:0007267

GO:0023052

GO:0031410

GO:0043226

GO:0043408

HMNXSV003036655

HMNXSV003040158

ILMN_1778143

PH_hs_0011380

TC22000319.hg

TC22001115.hg

g4758475_3p_a_at

Participates

as a component of

as an input of

as a member of

Adapter proteins [cytosol] (Homo sapiens)

Inferred To

grap2 [cytosol] (Xenopus tropicalis)

Grap2 [cytosol] (Mus musculus)

Grap2 [cytosol] (Rattus norvegicus)

GRAP2 [cytosol] (Bos taurus)

GRAP2 [cytosol] (Canis familiaris)

GRAP2 [cytosol] (Gallus gallus)

GRAP2 [cytosol] (Sus scrofa)

grap2a [cytosol] (Danio rerio)

drk [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001278753.1, NP_001278754.1, NP_004801.1, NP_001278757.1

OpenTargets

ENSG00000100351

ENSEMBL

ENSP00000339186, ENST00000407075, ENST00000344138, ENSP00000385607

HPA

ENSG00000100351-GRAP2

PRO

O75791

Pharos - Targets

O75791

PDB

5GJH

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.978	49
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.807	6
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.785	8
UniProt:Q9H706 GARE1			0.743	5
UniProt:Q9Y5A6 ZSC21			0.742	6
UniProt:Q13480 GAB1	4	p-Y-GAB1 [cytosol] (R-HSA-8855306) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.702	4
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) GAB2 [cytosol] (R-HSA-508239) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-Y-GAB2 [cytosol] (R-HSA-912529)	0.666	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q08460 Kcnma1	2	Kcnma1 [plasma membrane] (R-MMU-9667781) KCNMA1 [plasma membrane] (R-MMU-418462)	0.602	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.571	2
UniProt:Q9P2F9 ZN319			0.556	3
UniProt:P15622-3 ZNF250			0.556	3
UniProt:Q9H788 SH24A			0.556	5
UniProt:O43597 SPRY2	8	p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) SPRY2 [cytosol] (R-HSA-182949) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:Q8IY67 RAVR1			0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q7Z783 Q7Z783			0.556	3
UniProt:P0CG20 PRR35			0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:P30039 PBLD			0.556	3
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.553	2
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [specific granule membrane] (R-HSA-6799566) ADAM10 [tertiary granule membrane] (R-HSA-6800992)	0.544	3
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.527	2
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.527	2
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.527	3
UniProt:Q6AZZ1 TRIM68	1	TRIM68 [cytosol] (R-HSA-5624350)	0.527	2
UniProt:Q96J02 ITCH	2	Ub-C871-ITCH [cytosol] (R-HSA-8864515) ITCH [cytosol] (R-HSA-975995)	0.527	2
UniProt:Q96DE5 ANAPC16	2	ANAPC16 [cytosol] (R-HSA-6805138) ANAPC16 [nucleoplasm] (R-HSA-6805137)	0.527	2
UniProt:Q9NRM7 LATS2	2	p-S872,T1041-LATS2 [cytosol] (R-HSA-2028565) LATS2 [cytosol] (R-HSA-2028580)	0.488	2
UniProt:Q13064 MKRN3			0.488	2
UniProt:P15976-2 GATA1			0.488	2
UniProt:Q8TD31-3 CCHCR1			0.488	2
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q8ND90 PNMA1			0.488	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.488	2
UniProt:Q5JR59-3 MTUS2			0.488	2
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.488	2
UniProt:B4DXD0 B4DXD0			0.488	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.488	2
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.488	2
UniProt:Q8NA61-2 CBY2			0.488	2
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.488	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.488	2
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	4
UniProt:P41161-2 ETV5			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:Q8TF50 ZN526			0.488	2
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.488	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:P10747 CD28	3	p-Y191-CD28 [plasma membrane] (R-HSA-388756) CD28 [plasma membrane] (R-HSA-167632) CD28 [cytosol] (R-HSA-167628)	0.462	2

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