Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GRAP2 [cytosol]
Stable Identifier
R-HSA-202367
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GADS, GRB2-related adapter protein 2
Icon
Locations in the PathwayBrowser for interactor UniProt:Q13094 LCP2
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
Gads binds CD28 (Homo sapiens)
GRAP2 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Recruitment of Gads to LAT (Homo sapiens)
GRAP2 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3 binds to GRAP2 (Homo sapiens)
GRAP2 [cytosol] (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
GRAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75791 GRAP2
Gene Names
GRAP2, GADS, GRB2L, GRID
Chain
chain:1-330
Reference Genes
BioGPS Gene:9402 GRAP2
COSMIC (genes):GRAP2 GRAP2
CTD Gene:9402 GRAP2
dbSNP Gene:9402 GRAP2
ENSEMBL:ENSG00000100351 GRAP2
ENSEMBL_homo_sapiens_GENE:ENSG00000100351.17 GRAP2
HGNC:4563 GRAP2
KEGG Gene (Homo sapiens):9402 GRAP2
Monarch:9402 GRAP2
NCBI Gene:9402 GRAP2
OMIM:604518 GRAP2
Reference Transcript
RefSeq:NM_004810.3 GRAP2
RefSeq:NM_001291824.1 GRAP2
RefSeq:NM_001291825.1 GRAP2
RefSeq:NM_001291828.1 GRAP2
Other Identifiers
11750488_a_at
11752952_a_at
16930348
208406_PM_s_at
208406_s_at
38865_at
38866_at
38867_g_at
3946100
3946109
3946110
3946111
3946114
3946116
3946125
3946126
3946127
3946129
3946131
3946132
3946133
3946134
3946135
3946136
3946137
66212_at
8073194
9402
A_23_P143720
A_24_P10884
A_24_P408449
GE81443
GO:0001784
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0007165
GO:0007265
GO:0007267
GO:0023052
GO:0031410
GO:0043226
GO:0043408
HMNXSV003040158
ILMN_1778143
PH_hs_0011380
TC22000319.hg
g4758475_3p_a_at
Participates
as a component of
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
active FLT3:GRAP2 [plasma membrane] (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
GADS:SLP76 [cytosol] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
GADS:p-5Y-LAT [plasma membrane] (Homo sapiens)
as an input of
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
Active FLT3 binds to GRAP2 (Homo sapiens)
Gads binds CD28 (Homo sapiens)
Recruitment of Gads to LAT (Homo sapiens)
as a member of
Adapter proteins [cytosol] (Homo sapiens)
Inferred To
grap2 [cytosol]
(Xenopus tropicalis)
Grap2 [cytosol]
(Mus musculus)
Grap2 [cytosol]
(Rattus norvegicus)
GRAP2 [cytosol]
(Bos taurus)
GRAP2 [cytosol]
(Canis familiaris)
GRAP2 [cytosol]
(Gallus gallus)
GRAP2 [cytosol]
(Sus scrofa)
grap2a [cytosol]
(Danio rerio)
drk [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001278757.1
,
NP_001278753.1
,
NP_001278754.1
,
NP_004801.1
OpenTargets
ENSG00000100351
HPA
ENSG00000100351-GRAP2
GeneCards
O75791
Ensembl
ENSG00000100351
,
ENSP00000339186
,
ENSP00000385607
,
ENST00000407075
,
ENST00000344138
PRO
O75791
Pharos - Targets
O75791
PDB
5GJH
Interactors (61)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.978
49
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.807
6
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.785
8
UniProt:Q9H706 GARE1
0.743
5
UniProt:Q9Y5A6 ZSC21
0.742
6
UniProt:Q13480 GAB1
4
GAB1 [cytosol]
(R-HSA-179795)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.702
4
UniProt:Q9UQC2 GAB2
5
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
0.666
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
3
UniProt:Q08460 Kcnma1
2
Kcnma1 [plasma membrane]
(R-MMU-9667781)
KCNMA1 [plasma membrane]
(R-MMU-418462)
0.602
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.571
2
UniProt:P30039 PBLD
0.556
3
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.556
3
UniProt:P0CG20 PRR35
0.556
3
UniProt:Q7Z783 Q7Z783
0.556
3
UniProt:P00540 MOS
0.556
3
UniProt:Q8IY67 RAVR1
0.556
3
UniProt:O43597 SPRY2
8
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
0.556
3
UniProt:Q9H788 SH24A
0.556
5
UniProt:P15622-3 ZNF250
0.556
3
UniProt:Q9P2F9 ZN319
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.553
2
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.544
3
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
ANAPC16 [cytosol]
(R-HSA-6805138)
0.527
2
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.527
2
UniProt:Q6AZZ1 TRIM68
1
TRIM68 [cytosol]
(R-HSA-5624350)
0.527
2
UniProt:P40818 USP8
2
USP8 [cytosol]
(R-HSA-917720)
p-T945-USP8 [cytosol]
(R-HSA-1358714)
0.527
3
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.527
2
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.527
2
UniProt:Q9NRM7 LATS2
2
p-S872,T1041-LATS2 [cytosol]
(R-HSA-2028565)
LATS2 [cytosol]
(R-HSA-2028580)
0.488
2
UniProt:Q13064 MKRN3
0.488
2
UniProt:P15976-2 GATA1
0.488
2
UniProt:Q8TD31-3 CCHCR1
0.488
2
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.488
2
UniProt:Q8IYA8 IHO1
0.488
2
UniProt:Q8ND90 PNMA1
0.488
2
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.488
2
UniProt:Q5JR59-3 MTUS2
0.488
2
UniProt:P13646 KRT13
1
KRT13 [cytosol]
(R-HSA-6809591)
0.488
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
UniProt:Q08117-2 TLE5
0.488
2
UniProt:Q9Y2V7 COG6
2
COG6 [Golgi membrane]
(R-HSA-2980958)
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
0.488
2
UniProt:B4DXD0 B4DXD0
0.488
2
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.488
2
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.488
2
UniProt:Q8NA61-2 CBY2
0.488
2
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.488
2
UniProt:Q8TF50 ZN526
0.488
2
UniProt:Q9UKT9 IKZF3
0.488
2
UniProt:P41161-2 ETV5
0.488
2
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.488
4
IntAct:EBI-11742485 SSX2IP
0.488
2
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.488
2
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.488
2
UniProt:Q8N448 LNX2
0.488
2
UniProt:Q93062-3 RBPMS
0.488
2
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.488
2
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.488
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.488
2
UniProt:P10747 CD28
3
CD28 [cytosol]
(R-HSA-167628)
p-Y191-CD28 [plasma membrane]
(R-HSA-388756)
CD28 [plasma membrane]
(R-HSA-167632)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text