Reactome | ZAP70 [cytosol]

ZAP70 [cytosol]

Stable Identifier

R-HSA-202397

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ZAP-70, Tyrosine-protein kinase ZAP-70

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Locations in the PathwayBrowser for interactor UniProt:Q9Y2R2 PTPN22

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Literature References

PubMed ID	Title	Journal	Year
1423621	ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain Turck, CW, Iwashima, M, Weiss, A, Chan, AC	Cell	1992

External Reference Information

External Reference

UniProt:P43403 ZAP70

Gene Names

ZAP70, SRK

Chain

chain:1-619

Reference Genes

BioGPS Gene:7535 ZAP70

COSMIC (genes):ZAP70 ZAP70

CTD Gene:7535 ZAP70

dbSNP Gene:7535 ZAP70

ENSEMBL:ENSG00000115085 ZAP70

HGNC:12858 ZAP70

KEGG:hsa:7535 ZAP70

Monarch:7535 ZAP70

NCBI Gene:7535 ZAP70

OMIM:176947 ZAP70

UCSC:P43403 ZAP70

Reference Transcript

Other Identifiers

11728779_a_at

11728780_a_at

1498_at

1555613_PM_a_at

1555613_a_at

16883232

214032_PM_at

214032_at

2495188

2495189

2495190

2495195

2495196

2495197

2495198

2495199

2495203

2495204

2495205

2495207

2495208

2495209

2495210

2495211

2495212

2495213

2495214

2495215

2495216

2495217

2495218

2495219

2495220

2495221

2495222

2495223

2495224

2495225

2495226

2495227

2495229

7535

8043725

A_14_P123690

A_23_P39682

A_24_P169234

GE80046

GO:0001772

GO:0001784

GO:0002250

GO:0002376

GO:0002684

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006955

GO:0007155

GO:0007169

GO:0016020

GO:0016740

GO:0018108

GO:0019722

GO:0030154

GO:0030217

GO:0031234

GO:0035556

GO:0042101

GO:0042110

GO:0042113

GO:0043366

GO:0045059

GO:0045060

GO:0045061

GO:0045087

GO:0045121

GO:0045582

GO:0046632

GO:0046638

GO:0046641

GO:0048870

GO:0050776

GO:0050850

GO:0050852

GO:0070489

GO:0072678

GO:0098542

GO:0140096

HMNXSV003054871

HMNXSV003055697

Hs.234569.0.S1_3p_at

Hs.234569.0.S1_3p_x_at

Hs2.234569.2.S1_3p_s_at

ILMN_1674838

ILMN_1719756

ILMN_1804104

L05148_at

PH_hs_0027314

TC02000594.hg

Participates

as a member of

RHOH effectors [cytosol] (Homo sapiens)

as an output of

STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (Homo sapiens)

as an input of

Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)

as a component of

ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y315,Y493-ZAP70 [cytosol]

p-Y493-ZAP70 [cytosol]

Inferred To

Homologues of ZAP70 [cytosol] (Caenorhabditis elegans)

ZAP70 [cytosol] (Bos taurus)

ZAP70 [cytosol] (Caenorhabditis elegans)

ZAP70 [cytosol] (Canis familiaris)

ZAP70 [cytosol] (Danio rerio)

ZAP70 [cytosol] (Drosophila melanogaster)

ZAP70 [cytosol] (Gallus gallus)

ZAP70 [cytosol] (Mus musculus)

ZAP70 [cytosol] (Rattus norvegicus)

ZAP70 [cytosol] (Xenopus tropicalis)

Ghost homologue of ZAP70 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001070.2, NP_997402.1

ZINC - World Drugs

ZAP70_HUMAN

Guide to Pharmacology - Targets

2285

OpenTargets

ENSG00000115085

ENSEMBL

ENSP00000517110, ENST00000708154, ENSP00000513759, ENST00000708152, ENSP00000400475, ENST00000698508, ENST00000264972, ENST00000451498, ENSP00000264972, ENST00000708159, ENSP00000517109, ENSP00000517108

ZINC - FDA approved

ZAP70_HUMAN

ZINC - Substances

ZAP70_HUMAN

ZINC - Biogenic

ZAP70_HUMAN

ZINC target

P43403

PRO

P43403

GlyGen

P43403

PDB

3ZNI, 2OQ1, 4K2R, 4A4C, 2CBL, 4XZ0, 4XZ1, 4A4B, 2OZO, 5O76, 7SIY, 1U59, 2Y1N, 1M61, 1FBV

ZINC - Investigational

ZAP70_HUMAN

IntEnz

2.7.10.2

HPA

ENSG00000115085-ZAP70

Pharos - Targets

P43403

Orphanet

ZAP70

ZINC - Predictions - Purchasable

ZAP70_HUMAN

HMDB Protein

HMDBP01515

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20963 CD247			0.918	23
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.702	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.611	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.602	4
UniProt:Q8BGG7 UBS3B			0.591	10
UniProt:Q8N1K5-1 THEMIS			0.591	3
UniProt:P07766 CD3E	2	p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228) CD3E [plasma membrane] (R-HSA-197906)	0.527	3
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	2

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