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HS-GAGs translocate to the lysosome for degradation
Stable Identifier
R-HSA-2024084
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
lysosomal lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG degradation (Homo sapiens)
HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As part of the natural turnover of GAGs, extracellular HSPGs are endocytosed to the lysosome to be degraded (Winchester 2005).
Literature References
PubMed ID
Title
Journal
Year
15647514
Lysosomal metabolism of glycoproteins
Winchester, B
Glycobiology
2005
Participants
Input
HS/HPIN-PGs [plasma membrane]
(Homo sapiens)
Output
HS/HPIN-PGs [lysosomal lumen]
(Homo sapiens)
Participates
as an event of
HS-GAG degradation (Homo sapiens)
Event Information
Go Biological Process
endocytosis (0006897)
Orthologous Events
HS-GAGs translocate to the lysosome for degradation (Bos taurus)
HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)
HS-GAGs translocate to the lysosome for degradation (Canis familiaris)
HS-GAGs translocate to the lysosome for degradation (Danio rerio)
HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)
HS-GAGs translocate to the lysosome for degradation (Gallus gallus)
HS-GAGs translocate to the lysosome for degradation (Mus musculus)
HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)
HS-GAGs translocate to the lysosome for degradation (Sus scrofa)
HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)
Authored
Jassal, B (2011-12-14)
Reviewed
Hill, DP (2022-05-20)
D'Eustachio, P (2012-03-28)
Created
Jassal, B (2011-12-14)
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