HS-GAG degradation

Stable Identifier
R-HSA-2024096
DOI
10.3180/R-HSA-2024096.2
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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HS-GAG degradation
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Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of heparan sulfate/heparin. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.
Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
heparan sulfate proteoglycan catabolic process (0030200)
Orthologous Events
HS-GAG degradation (Bos taurus)
HS-GAG degradation (Caenorhabditis elegans)
HS-GAG degradation (Canis familiaris)
HS-GAG degradation (Danio rerio)
HS-GAG degradation (Dictyostelium discoideum)
HS-GAG degradation (Drosophila melanogaster)
HS-GAG degradation (Gallus gallus)
HS-GAG degradation (Mus musculus)
HS-GAG degradation (Rattus norvegicus)
HS-GAG degradation (Sus scrofa)
HS-GAG degradation (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-14)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-14)
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