Phosphorylation of CARMA1

Stable Identifier
R-HSA-202437
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of CARMA1
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Antigen receptor triggered PKC theta dependent linker phosphorylation of S559 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment (Sommer et al. 2005). PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.

Literature References
PubMed ID Title Journal Year
16356855 Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Sommer, K, Pomerantz, JL, Rawlings, DJ, Guo, B, Bandaranayake, AD, Ovechkina, YL, Moreno-Garcia, ME

Immunity 2005
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Weil, R, Thome, M

Trends Immunol 2007
16356853 Phosphorylation of CARMA1: the link(er) to NF-kappaB activation

Rueda, D, Thome, M

Immunity 2005
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Active PKC theta bound to DAG [plasma membrane]

Physical Entity
Active PKC theta bound to DAG [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of CARMA1 (Bos taurus)
Phosphorylation of CARMA1 (Canis familiaris)
Phosphorylation of CARMA1 (Danio rerio)
Phosphorylation of CARMA1 (Mus musculus)
Phosphorylation of CARMA1 (Sus scrofa)
Authored
Garapati, P V  (2008-01-24)
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)
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