Reactome | MALT1 [cytosol]

MALT1 [cytosol]

Stable Identifier

R-HSA-202461

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Activation of NF-kappaB in B cells (Homo sapiens)
        
        CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10:TAK1 [plasma membrane] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Downstream TCR signaling (Homo sapiens)
      - Activation of IKK complex (Homo sapiens)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Activation of TAK1-TAB2 complex (Homo sapiens)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Auto-ubiquitination of TRAF6 (Homo sapiens)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Translocation of TRAF6 to CBM complex (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - CLEC7A/inflammasome pathway (Homo sapiens)
        
        ASC binds Caspase-8 complex (Homo sapiens)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Caspase-8 binds MALT (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Caspase-8 cleaves IL1B precursor (Homo sapiens)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - K63polyUb-TAK1 autophosphorylates (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - MALT1 binds BCL10 (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10 oligomers:MALT1 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - MALT1 oligomerizes (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10 oligomers:MALT1 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRAF6 binds MALT1 oligomers (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRAF6 oligomer autoubiquitinates (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRAF6 oligomerizes (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated NF-kB activation (Homo sapiens)
      - Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Auto-ubiquitination of TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)
        
        BCL10:MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM complex [plasma membrane] (Homo sapiens)
        
        p-CARMA1 oligomer:BCL10:MALT1 (CBM complex) [plasma membrane] (Homo sapiens)
        
        BCL10:MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Oligomerization of BCL10 and MALT1 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM complex [plasma membrane] (Homo sapiens)
        
        p-CARMA1 oligomer:BCL10:MALT1 (CBM complex) [plasma membrane] (Homo sapiens)
        
        BCL10:MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Oligomerization of TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Phosphorylation of IKK-beta by TAK1 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UDY8 MALT1

Gene Names

MALT1, MLT

Chain

initiator methionine:, chain:2-824

Reference Genes

COSMIC (genes):MALT1 MALT1

ENSEMBL:ENSG00000172175 MALT1

Participates

as an input of

as a component of

as a repeated unit of

MALT1 oligomer [cytosol] (Homo sapiens)

Inferred To

Homologues of MALT1 [cytosol] (Dictyostelium discoideum)

malt-1 [cytosol] (Caenorhabditis elegans)

pcp [cytosol] (Dictyostelium discoideum)

PCASP1 [cytosol] (Gallus gallus)

Malt1 [cytosol] (Mus musculus)

Malt1 [cytosol] (Rattus norvegicus)

MALT1 [cytosol] (Bos taurus)

MALT1 [cytosol] (Canis familiaris)

MALT1 [cytosol] (Dictyostelium discoideum)

MALT1 [cytosol] (Sus scrofa)

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.942	24
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.688	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.656	4
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.589	2
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.558	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.524	4
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.524	2
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.499	10
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cilium] (R-HSA-5632507) CSNK1A1 [cytosol] (R-HSA-195263)	0.499	7

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