Reactome | Formation of a heteromeric BMP receptor complex

Formation of a heteromeric BMP receptor complex

Stable Identifier

R-HSA-202604

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Formation of a heteromeric BMP receptor complex

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BMP receptors, unlike TGF-beta receptors are known to form hetero-oligomeric complexes in the endoplasmic reticulum and are transported as oligomers to the plasma membrane where they bind ligand. However, evidence for ligand-induced heteromeric BMP receptor complexes on the cell surface has also been published, leading to a model where both pre-formed and ligand-induced receptor oligomers are encountered on the plasma membrane. Based on the latter, a theory has been formulated that suggests that the signaling outcome from pre-formed and ligand-induced BMP receptor complexes is different. The mechanism that might explain this theory must involve different ways of internalization and trafficking of the BMP receptor complexes.

Literature References

PubMed ID	Title	Journal	Year
10712517	Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors Nohe, A, Geissendorfer, T, Knaus, P, Henis, YI, Sebald, W, Gilboa, L	Mol Biol Cell	2000
16672363	Structure of the ternary signaling complex of a TGF-beta superfamily member Choe, S, Allendorph, GP, Vale, WW	Proc Natl Acad Sci U S A	2006
11714695	The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways Neubauer, F, Ehrlich, M, Nohe, A, Knaus, P, Henis, YI, Sebald, W, Hassel, S	J Biol Chem	2002