Reactome | PIP3 binds to RhoA and activates it

PIP3 binds to RhoA and activates it

Stable Identifier

R-HSA-202692

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G-protein beta:gamma signalling (Homo sapiens)
      - G beta:gamma signalling through PI3Kgamma (Homo sapiens)
        
        PIP3 binds to RhoA and activates it (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - PI3K/AKT activation (Homo sapiens)
        
        PIP3 binds to RhoA and activates it (Homo sapiens)

General

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Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT (Chong et al. 1994, Oude Weernink et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
17245604	Phospholipase D signaling: orchestration by PIP2 and small GTPases Schmidt, M, Oude Weernink, PA, López de Jesús, M	Naunyn Schmiedebergs Arch Pharmacol	2007
7954816	The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells Schwartz, MA, Traynor-Kaplan, A, Bokoch, GM, Chong, LD	Cell	1994
23669310	Signaling networks of Rho GTPases in cell motility El-Sibai, M, Hanna, S	Cell. Signal.	2013