CD177 binds PECAM-1

Stable Identifier
R-HSA-202702
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CD177 binds PECAM-1
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CD177 is a 58- to 64-kDa glycosylphosphatidylinositol-anchored glycoprotein expressed exclusively by neutrophils, neutrophilic metamyelocytes, and myelocytes, but not by any other blood cells. It has been shown that neutrophil-specific CD177 is a heterophilic binding partner of PECAM-1, constituting a novel pathway that promotes neutrophil transmigration.

Literature References
PubMed ID Title Journal Year
17580308 The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)

Choi, EY, Santoso, S, Orlova, VV, Andrei-Selmer, CL, Preissner, KT, Newman, PJ, Maniar, A, Chavakis, T, Weiss, T, Sachs, UJ, Paddock, C

J Biol Chem 2007
17116209 PECAM-1, a key player in neuroinflammation

Losy, J, Kalinowska, A

Eur J Neurol 2006
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Orthologous Events
CD177 binds PECAM-1 (Bos taurus)
CD177 binds PECAM-1 (Canis familiaris)
CD177 binds PECAM-1 (Mus musculus)
CD177 binds PECAM-1 (Rattus norvegicus)
CD177 binds PECAM-1 (Sus scrofa)
Authored
Ouwehand, WH  (2007-11-12)
Reviewed
Zwaginga, JJ  (2007-11-12)
Created
de Bono, B  (2007-11-11)
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