Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)

Stable Identifier
Reaction [binding]
Homo sapiens
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JAM-A plays a key role in leukocyte transmigration and inflammatory extravasation. Transmigration of human leukocytes has been shown to involve heterophilic interactions of JAM-A with its integrin receptor LFA-1.

Literature References
PubMed ID Title Journal Year
15681301 Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A

Liehn, EA, Weber, C, Fraemohs, L, Lietz, M, Baltus, T, Zernecke, A, Schober, A, Ostermann, G

Arterioscler Thromb Vasc Biol 2005
15528364 The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain

Weber, C, Fraemohs, L, Koenen, RR, Heinemann, B, Ostermann, G

J Immunol 2004
11812992 JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes

Weber, C, Weber, KS, Zernecke, A, Ostermann, G, Schroder, A

Nat Immunol 2002
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
Orthologous Events
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