Reactome | JAM2 binds JAM3

JAM2 binds JAM3

Stable Identifier

R-HSA-202721

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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JAM2 and JAM3 bind each other and are strongly expressed by endothelial cells of high endothelial venules, the predominant site of leukocyte extravasation. JAM2 and JAM3 also bind to the leukocyte integrins VLA-4 and Mac-1 respectively.

Literature References

PubMed ID	Title	Journal	Year
16297198	Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation Ludwig, RJ, Baatz, H, Santoso, S, Podda, M, Hardt, K, Boehncke, WH, Gille, J, Pfeffer, J, Schon, MP, Zollner, TM, Johann, PS, Kaufmann, R, Radeke, HH	J Invest Dermatol	2005
17525755	The role of junctional adhesion molecules in vascular inflammation Weber, C, Fraemohs, L, Dejana, E	Nat Rev Immunol	2007