Reactome | P-selectin binds P-selectin ligand

P-selectin binds P-selectin ligand

Stable Identifier

R-HSA-202724

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all four selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.

Literature References

PubMed ID	Title	Journal	Year
7521878	The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine Lyons, DE, Cummings, RD, Lichenstein, HS, Moore, KL, Eaton, SF, McEver, RP	J. Biol. Chem.	1994
17322099	P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium Horrevoets, AJ, Zwaginga, JJ, Hordijk, PL, Beckers, C, Fernandez-Borja, M, van Thienen, JV, van Gils, JM, Garcia-Vallejo, JJ, da Costa Martins, P	Arterioscler Thromb Vasc Biol	2007
14615387	Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation Ulfman, LH, Zwaginga, JJ, Hordijk, PL, van den Berk, N, Koenderman, L, da Costa Martins, P	Arterioscler Thromb Vasc Biol	2004